Late-stage diversification of natural products is an efficient way to generate natural product
derivatives for drug discovery and chemical biology. Benefiting from the development of site …

Conspectus Steroids, termed “keys to life” by Rupert Witzmann, have a wide variety of
biological activities, including anti-inflammatory, antishock, immunosuppressive, stress …

We disclose unified, protecting-group-free, bioinspired divergent total syntheses of eight allo-
cedrane and seco-prezizaane Illicium sesquiterpenes and formal syntheses of five …

We have accomplished the total synthesis of sculponin U, a polycyclic C‐20‐oxygenated
kaurane diterpenoid featuring a 7, 20‐lactone‐hemiketal bridge, through a radical cascade …

The first asymmetric total synthesis of the hexacyclic veatchine-type C20-diterpenoid
alkaloid (−)-garryine is presented. Key steps include a Pd-catalyzed enantioselective Heck …

An asymmetric approach for the first total synthesis of (−)-rhodomollanol A, a highly oxidized
diterpenoid, is described. The efficient synthetic strategy features three key …

Covering: 2015 to 2020 The ent-kaurane diterpenoids are integral parts of tetracyclic natural
products that are widely distributed in terrestrial plants. These compounds have been found …

Conspectus Polycyclic natural products are an inexhaustible source of medicinal agents,
and their complex molecular architecture renders challenging synthetic targets where …

Total synthesis of natural products has been an important pursuit in chemical synthesis due
to their fascinating structural complexity and/or interesting biological activities. In most …

Covering: 2016 to 2023The synthetic chemistry community is always in pursuit of efficient
routes to natural products. Among the many available general strategies, skeletal …