Ferroptosis in cancer and cancer immunotherapy
The hallmark of tumorigenesis is the successful circumvention of cell death regulation for
achieving unlimited replication and immortality. Ferroptosis is a newly identified type of cell …
achieving unlimited replication and immortality. Ferroptosis is a newly identified type of cell …
Neuroprotective effect of antioxidants in the brain
KH Lee, M Cha, BH Lee - International journal of molecular sciences, 2020 - mdpi.com
The brain is vulnerable to excessive oxidative insults because of its abundant lipid content,
high energy requirements, and weak antioxidant capacity. Reactive oxygen species (ROS) …
high energy requirements, and weak antioxidant capacity. Reactive oxygen species (ROS) …
Amplification of lipid peroxidation by regulating cell membrane unsaturation to enhance chemodynamic therapy
Y Zhu, P Gong, J Wang, J Cheng… - Angewandte Chemie …, 2023 - Wiley Online Library
Lipid peroxidation (LPO) is one of the most damaging processes in chemodynamic therapy
(CDT). Although it is well known that polyunsaturated fatty acids (PUFAs) are much more …
(CDT). Although it is well known that polyunsaturated fatty acids (PUFAs) are much more …
[HTML][HTML] Insight into the mechanism of ferroptosis inhibition by ferrostatin-1
Ferroptosis is a form of cell death primed by iron and lipid hydroperoxides and prevented by
GPx4. Ferrostatin-1 (fer-1) inhibits ferroptosis much more efficiently than phenolic …
GPx4. Ferrostatin-1 (fer-1) inhibits ferroptosis much more efficiently than phenolic …
Ferroptosis, a novel pharmacological mechanism of anti-cancer drugs
Y Su, B Zhao, L Zhou, Z Zhang, Y Shen, H Lv… - Cancer letters, 2020 - Elsevier
Ferroptosis, a form of regulated cell death, is initiated by oxidative perturbations of the
intracellular microenvironment, which is under the constitutive control of glutathione …
intracellular microenvironment, which is under the constitutive control of glutathione …
The development of the concept of ferroptosis
T Hirschhorn, BR Stockwell - Free Radical Biology and Medicine, 2019 - Elsevier
The term ferroptosis was coined in 2012 to describe an iron-dependent regulated form of
cell death caused by the accumulation of lipid-based reactive oxygen species; this type of …
cell death caused by the accumulation of lipid-based reactive oxygen species; this type of …
[HTML][HTML] 13 reasons why the brain is susceptible to oxidative stress
The human brain consumes 20% of the total basal oxygen (O 2) budget to support ATP
intensive neuronal activity. Without sufficient O 2 to support ATP demands, neuronal activity …
intensive neuronal activity. Without sufficient O 2 to support ATP demands, neuronal activity …
Ferroptosis in cancer cell biology
CM Bebber, F Müller, L Prieto Clemente, J Weber… - Cancers, 2020 - mdpi.com
A major hallmark of cancer is successful evasion of regulated forms of cell death. Ferroptosis
is a recently discovered type of regulated necrosis which, unlike apoptosis or necroptosis, is …
is a recently discovered type of regulated necrosis which, unlike apoptosis or necroptosis, is …
Mechanisms of ferroptosis
JY Cao, SJ Dixon - Cellular and Molecular Life Sciences, 2016 - Springer
Ferroptosis is a non-apoptotic form of cell death that can be triggered by small molecules or
conditions that inhibit glutathione biosynthesis or the glutathione-dependent antioxidant …
conditions that inhibit glutathione biosynthesis or the glutathione-dependent antioxidant …
[HTML][HTML] Regulation of ferroptotic cancer cell death by GPX4
Ferroptosis is a form of nonapoptotic cell death for which key regulators remain unknown.
We sought a common mediator for the lethality of 12 ferroptosis-inducing small molecules …
We sought a common mediator for the lethality of 12 ferroptosis-inducing small molecules …