The hallmark of tumorigenesis is the successful circumvention of cell death regulation for
achieving unlimited replication and immortality. Ferroptosis is a newly identified type of cell …

The brain is vulnerable to excessive oxidative insults because of its abundant lipid content,
high energy requirements, and weak antioxidant capacity. Reactive oxygen species (ROS) …

Lipid peroxidation (LPO) is one of the most damaging processes in chemodynamic therapy
(CDT). Although it is well known that polyunsaturated fatty acids (PUFAs) are much more …

Ferroptosis is a form of cell death primed by iron and lipid hydroperoxides and prevented by
GPx4. Ferrostatin-1 (fer-1) inhibits ferroptosis much more efficiently than phenolic …

Ferroptosis, a form of regulated cell death, is initiated by oxidative perturbations of the
intracellular microenvironment, which is under the constitutive control of glutathione …

The term ferroptosis was coined in 2012 to describe an iron-dependent regulated form of
cell death caused by the accumulation of lipid-based reactive oxygen species; this type of …

The human brain consumes 20% of the total basal oxygen (O 2) budget to support ATP
intensive neuronal activity. Without sufficient O 2 to support ATP demands, neuronal activity …

A major hallmark of cancer is successful evasion of regulated forms of cell death. Ferroptosis
is a recently discovered type of regulated necrosis which, unlike apoptosis or necroptosis, is …

Ferroptosis is a non-apoptotic form of cell death that can be triggered by small molecules or
conditions that inhibit glutathione biosynthesis or the glutathione-dependent antioxidant …

Ferroptosis is a form of nonapoptotic cell death for which key regulators remain unknown.
We sought a common mediator for the lethality of 12 ferroptosis-inducing small molecules …