Iron acquisition systems of gram-negative bacterial pathogens define TonB-dependent pathways to novel antibiotics
Iron is an indispensable metabolic cofactor in both pro-and eukaryotes, which engenders a
natural competition for the metal between bacterial pathogens and their human or animal …
natural competition for the metal between bacterial pathogens and their human or animal …
[HTML][HTML] Small molecule anti-biofilm agents developed on the basis of mechanistic understanding of biofilm formation
K Qvortrup, LD Hultqvist, M Nilsson… - Frontiers in …, 2019 - frontiersin.org
Microbial biofilms are the cause of persistent infections associated with various medical
implants and distinct body sites such as the urinary tract, lungs, and wounds. Compared with …
implants and distinct body sites such as the urinary tract, lungs, and wounds. Compared with …
Pyoverdine, a siderophore from Pseudomonas aeruginosa, translocates into C. elegans, removes iron, and activates a distinct host response
Pseudomonas aeruginosa, a re-emerging, opportunistic human pathogen, encodes a
variety of virulence determinants. Pyoverdine, a siderophore produced by this bacterium, is …
variety of virulence determinants. Pyoverdine, a siderophore produced by this bacterium, is …
The action of phytochemicals in biofilm control
ASC Gonçalves, MM Leitão, M Simões… - Natural Product …, 2023 - pubs.rsc.org
Covering: 2009 to 2021 Antimicrobial resistance is now rising to dangerously high levels in
all parts of the world, threatening the treatment of an ever-increasing range of infectious …
all parts of the world, threatening the treatment of an ever-increasing range of infectious …
[HTML][HTML] Pyoverdine-Dependent Virulence of Pseudomonas aeruginosa Isolates From Cystic Fibrosis Patients
The development of therapies that modulate or prevent pathogen virulence may be a key
strategy for circumventing antimicrobial resistance. Toward that end, we examined the …
strategy for circumventing antimicrobial resistance. Toward that end, we examined the …
Interdependence between iron acquisition and biofilm formation in Pseudomonas aeruginosa
D Kang, NV Kirienko - Journal of microbiology, 2018 - Springer
Bacterial biofilms remain a persistent threat to human healthcare due to their role in the
development of antimicrobial resistance. To combat multi-drug resistant pathogens, it is …
development of antimicrobial resistance. To combat multi-drug resistant pathogens, it is …
[HTML][HTML] Rapid Diagnosis of Pseudomonas aeruginosa in Wounds with Point-Of-Care Fluorescence Imaing
R Raizman, W Little, AC Smith - Diagnostics, 2021 - mdpi.com
Pseudomonas aeruginosa (PA) is a common bacterial pathogen in chronic wounds known
for its propensity to form biofilms and evade conventional treatment methods. Early detection …
for its propensity to form biofilms and evade conventional treatment methods. Early detection …
Acquisition of regulator on virulence plasmid of hypervirulent Klebsiella allows bacterial lifestyle switch in response to iron
Hypervirulent Klebsiella pneumoniae causes liver abscess and potentially devastating
metastatic complications. The majority of Klebsiella-induced liver abscess are caused by the …
metastatic complications. The majority of Klebsiella-induced liver abscess are caused by the …
[HTML][HTML] Novel Pyoverdine Inhibitors Mitigate Pseudomonas aeruginosa Pathogenesis
Pseudomonas aeruginosa is a clinically important pathogen that causes a variety of
infections, including urinary, respiratory, and other soft-tissue infections, particularly in …
infections, including urinary, respiratory, and other soft-tissue infections, particularly in …
[HTML][HTML] PqsA promotes pyoverdine production via biofilm formation
D Kang, KE Turner, NV Kirienko - Pathogens, 2017 - mdpi.com
Biofilms create an impermeable barrier against antimicrobial treatment and immune cell
access, severely complicating treatment and clearance of nosocomial Pseudomonas …
access, severely complicating treatment and clearance of nosocomial Pseudomonas …