Abstract The phosphatidylinositol 3-kinase (PI3K)/Akt pathway plays a crucial role in various
cellular processes and is aberrantly activated in cancers, contributing to the occurrence and …

Phosphoinositide 3-kinase (PI3K) activity is stimulated by diverse oncogenes and growth
factor receptors, and elevated PI3K signaling is considered a hallmark of cancer. Many PI3K …

Only a small percentage of patients afflicted with gastric cancer (GC) respond to immune
checkpoint blockade (ICB). To study the mechanisms underlying this resistance, we …

PI3Ks regulate several key events in the inflammatory response to damage and infection.
There are four Class I PI3K isoforms (PI3Kα, β, γ, δ), three Class II PI3K isoforms (PI3KC2α …

Primary immunodeficiencies are inherited disorders of the immune system, often caused by
the mutation of genes required for lymphocyte development and activation. Recently …

Inhibitors against the p110δ isoform of phosphoinositide-3-OH kinase (PI (3) K) have shown
remarkable therapeutic efficacy in some human leukaemias,. As p110δ is primarily …

Duvelisib is an oral dual inhibitor of phosphoinositide 3-kinase-δ (PI3K-δ) and PI3K-γ in late-
stage clinical development for hematologic malignancy treatment. This phase 1 study …

Antigen-experienced memory T cells acquire effector function with innate-like kinetics;
however, the metabolic requirements of these cells are unknown. Here we show that rapid …

Idelalisib is a small-molecule inhibitor of PI3Kδ with demonstrated efficacy for the treatment
of relapsed/refractory chronic lymphocytic leukemia (CLL). To evaluate idelalisib as front …

Abstract The PI3K/AKT signaling pathway is an essential node in mammalian cells that
controls cell growth, migration, proliferation, and metabolism. During the last decade, a …