The coronavirus spike protein is a multifunctional molecular machine that mediates
coronavirus entry into host cells. It first binds to a receptor on the host cell surface through its …

Coronaviruses (CoVs) have a remarkable potential to change tropism. This is particularly
illustrated over the last 15 years by the emergence of two zoonotic CoVs, the severe acute …

Abstract The 2019 novel coronavirus (2019-nCoV/SARS-CoV-2) originally arose as part of a
major outbreak of respiratory disease centered on Hubei province, China. It is now a global …

Traditionally, the emergence of coronaviruses (CoVs) has been attributed to a gain in
receptor binding in a new host. Our previous work with severe acute respiratory syndrome …

Coronaviruses are a group of viruses causing disease in a wide range of animals, and
humans. Since 2002, the successive emergence of bat-borne severe acute respiratory …

Coronaviruses are large, enveloped RNA viruses of both medical and veterinary
importance. Interest in this viral family has intensified in the past few years as a result of the …

Coronaviruses are a family of enveloped, single-stranded, positive-strand RNA viruses
classified within the Nidovirales order. This coronavirus family consists of pathogens of …

Coronavirus protease nsp5 (M pro, 3CL pro) remains a primary target for coronavirus
therapeutics due to its indispensable and conserved role in the proteolytic processing of the …

Over the past 30 years, several cross-species transmission events, as well as changes in
virus tropism, have mediated significant animal and human diseases. Most notable is severe …

Publisher Summary This chapter discusses the manipulation of clones of coronavirus and of
complementary DNAs (cDNAs) of defective-interfering (DI) RNAs to study coronavirus RNA …