The inherited basis of diabetes mellitus: implications for the genetic analysis of complex traits

JC Florez, J Hirschhorn… - Annual review of genomics …, 2003 - annualreviews.org
Diabetes encompasses a heterogeneous group of diseases, each with a substantial genetic
component. We review the division of diabetes into different subtypes based on clinical …

[HTML][HTML] The genetics of gestational diabetes mellitus: evidence for relationship with type 2 diabetes mellitus

J Robitaille, AM Grant - Genetics in Medicine, 2008 - Elsevier
Gestational diabetes is a major public health problem because of its prevalence, its
associated complications during pregnancy, and its increased risk for type 2 diabetes later in …

A genome-wide scan for coronary heart disease suggests in Indo-Mauritians a susceptibility locus on chromosome 16p13 and replicates linkage with the metabolic …

S Francke, M Manraj, C Lacquemant… - Human Molecular …, 2001 - academic.oup.com
Prevalence of coronary heart disease (CHD), of type 2 diabetes (T2DM) and of the metabolic
syndrome are in Mauritius amongst the highest in the world. As T2DM and CHD are closely …

[PDF][PDF] Vitamin D receptor (FokI, BsmI and TaqI) gene polymorphisms and type 2 diabetes mellitus: a North Indian study

HK Bid, R Konwar, CG Aggarwal, S Gautam… - Indian J Med …, 2009 - researchgate.net
ABSTRACT BACKGROUND: The vitamin D receptor (VDR) gene is a candidate gene for
susceptibility to several diseases. Studies on association between VDR polymorphisms and …

Genetic predisposition to type 2 diabetes among Asian Indians

V Radha, V Mohan - Indian Journal of Medical Research, 2007 - journals.lww.com
Genes play an important role in the development of diabetes mellitus. Type 2 diabetes is a
polygenic disorder with multiple genes located on different chromosomes contributing to its …

Gly972Arg variant in the insulin receptor substrate-1 gene and association with Type 2 diabetes: a meta-analysis of 27 studies

A Jellema, MPA Zeegers, EJM Feskens, PC Dagnelie… - Diabetologia, 2003 - Springer
Aims/hypothesis Several case-control studies have examined the association between the
Gly972Arg variant in the IRS-1 gene and Type 2 diabetes, but most had limited power and …

Candidate genes for type 2 diabetes

H Parikh, L Groop - Reviews in Endocrine and Metabolic Disorders, 2004 - Springer
About 150 million people suffer from type 2 diabetes in the world today and it has been
predicted that this number will be doubled within 15 years [1]. It is no longer a disease of the …

Type 2 diabetes in South Asians: a pathophysiologic focus on the Asian-Indian epidemic

M Bajaj, MA Banerji - Current diabetes reports, 2004 - Springer
There is a high prevalence of type 2 diabetes mellitus and coronary artery disease among
urban and migrant Asian Indians, despite the absence of traditional risk factors. Evidence …

[PDF][PDF] Mutation screening of the PPARalpha, gene in type 2 diabetes associated with coronary heart disease

C Lacquemant, F Lepretre, IP Torra… - Diabetes and …, 2000 - researchgate.net
The peroxisome proliferator-activated receptor alpha (PPARα) is a ligand-activated
transcription factor belonging to the nuclear hormone receptor superfamily. PPARα plays a …

The human obesity gene map: the 1998 update

L Pérusse, YC Chagnon, J Weisnagel… - Obesity …, 1999 - Wiley Online Library
Abstract PÉRUSSE, LOUIS, YVON C. CHAGNON, JOHN WEISNAGEL, AND CLAUDE
BOUCHARD. The human obesity gene map: the 1998 update. Obes Res. 1999; 7: 111–129 …