Multifaced role of protein deacetylase sirtuins in neurodegenerative disease
Sirtuins, a class III histone/protein deacetylase, is a central regulator of metabolic function
and cellular stress response. This plays a pivotal role in the pathogenesis and progression …
and cellular stress response. This plays a pivotal role in the pathogenesis and progression …
Chromatin dynamics and DNA replication roadblocks
I Hammond-Martel, A Verreault, H Wurtele - DNA repair, 2021 - Elsevier
A broad spectrum of spontaneous and genotoxin-induced DNA lesions impede replication
fork progression. The DNA damage response that acts to promote completion of DNA …
fork progression. The DNA damage response that acts to promote completion of DNA …
BZD9L1 sirtuin inhibitor as a potential adjuvant for sensitization of colorectal cancer cells to 5-fluorouracil
Background: This study aims to investigate the combination effect of a novel sirtuin inhibitor
(BZD9L1) with 5-fluorouracil (5-FU) and to determine its molecular mechanism of action in …
(BZD9L1) with 5-fluorouracil (5-FU) and to determine its molecular mechanism of action in …
Chromatin as a platform for modulating the replication stress response
LA Fournier, A Kumar, PC Stirling - Genes, 2018 - mdpi.com
Eukaryotic DNA replication occurs in the context of chromatin. Recent years have seen
major advances in our understanding of histone supply, histone recycling and nascent …
major advances in our understanding of histone supply, histone recycling and nascent …
A subtelomeric region affects telomerase-negative replicative senescence in Saccharomyces cerevisiae
In eukaryotes, telomeres determine cell proliferation potential by triggering replicative
senescence in the absence of telomerase. In Saccharomyces cerevisiae, senescence is …
senescence in the absence of telomerase. In Saccharomyces cerevisiae, senescence is …
Persistent Acetylation of Histone H3 Lysine 56 Compromises the Activity of DNA Replication Origins
In Saccharomyces cerevisiae, newly synthesized histones H3 are acetylated on lysine 56
(H3 K56ac) by the Rtt109 acetyltransferase prior to their deposition on nascent DNA behind …
(H3 K56ac) by the Rtt109 acetyltransferase prior to their deposition on nascent DNA behind …
DNA damage, sirtuins, and epigenetic marks
DK Alves-Fernandes, MG Jasiulionis - Epigenetics and DNA Damage, 2022 - Elsevier
Sirtuins are class III NAD+-dependent histone deacetylases (HDACs), able to modify several
proteins, including histones. Due to their deacetylase activity in histones, they are involved …
proteins, including histones. Due to their deacetylase activity in histones, they are involved …
Impact de la structure de la chromatine naissante sur la réponse aux stress réplicatifs
R Tremblay - 2024 - papyrus.bib.umontreal.ca
L'usage de composé chimique causant des dommages à l'ADN en phase S est une
stratégie couramment utilisée en chimiothérapie du cancer. Ainsi, l'étude de la réponse …
stratégie couramment utilisée en chimiothérapie du cancer. Ainsi, l'étude de la réponse …
Persistent acetylation of newly synthesized histones inhibits DNA replication origin activity
Histone acetylation is a known regulator of DNA replication dynamics. In the yeast
Saccharomyces cerevisiae, newly synthesized histone H3 deposited behind DNA …
Saccharomyces cerevisiae, newly synthesized histone H3 deposited behind DNA …