A link between oxidative stress and hypertension has been firmly established in multiple
animal models of hypertension but remains elusive in humans. While initial studies focused …

Significance: Intrarenal oxidative stress plays a critical role in the initiation and progression
of diabetic kidney disease (DKD). Enhanced oxidative stress results from overproduction of …

Intrarenal autoregulatory mechanisms maintain renal blood flow (RBF) and glomerular
filtration rate (GFR) independent of renal perfusion pressure (RPP) over a defined range (80 …

atherosclerosis, hypertension, cardiac hypertrophy and remodeling, angiogenesis and
collateral formation, stroke, and heart failure. In this review, we discuss in detail the …

Oxidative stress has been implicated in the pathophysiology of diabetic nephropathy.
Studies in experimental animal models of diabetes strongly implicate oxidant species as a …

Significance: Reactive oxygen species (ROS) play a critical role in vascular disease. While
there are many possible sources of ROS, nicotinamide adenine dinucleotide phosphate …

Increased vascular production of reactive oxygen species (ROS; termed oxidative stress)
has been implicated in various chronic diseases, including hypertension. Oxidative stress is …

Reactive oxygen species are ubiquitous signaling molecules in biological systems. Four
members of the NADPH oxidase (Nox) enzyme family are important sources of reactive …

Reactive oxygen species (ROS) influence many physiological processes including host
defense, hormone biosynthesis, fertilization, and cellular signaling. Increased ROS …

Unilateral ureteral obstruction (UUO) is an experimental rodent model that mimics renal
fibrosis associated with obstructive nephropathy in an accelerated manner. After UUO, the …