A fundamental question in developmental immunology is how bipotential thymocyte
precursors generate both CD4+ helper and CD8+ cytotoxic T cell lineages. The MHC …

Precise gene expression ensures proper stem and progenitor cell differentiation, lineage
commitment and organogenesis during mammalian development. ATP-dependent …

Helios, a member of the Ikaros transcription factor family, is preferentially expressed at the
mRNA level by regulatory T cells (Treg cells). We evaluated Helios protein expression using …

The transcription factor Helios has been reported to be a marker of regulatory T cells (Treg)
of thymic origin, distinguishing them from Treg induced in the periphery (iTreg). In this study …

Transcription regulation through chromatin compaction and decompaction is regulated
through various chromatin-remodeling complexes such as nucleosome remodeling and …

Transcription factor IKZF1 (IKAROS) acts as a critical regulator of lymphoid differentiation
and is frequently deleted or mutated in B-cell precursor acute lymphoblastic leukemia. IKZF1 …

The Ikaros family transcription factors regulate lymphocyte development. Loss-of-function
variants in IKZF1 cause primary immunodeficiency, but Ikaros family members IKZF2 and …

The transcription factor Ikaros is an essential regulator of lymphopoiesis. Here we studied its
B cell–specific function by conditional inactivation of the gene encoding Ikaros (Ikzf1) in pro …

Relative upregulation of the Ikaros family transcription factor Helios in natural regulatory T
cells (Tregs) has been reported by several groups. However, a role for Helios in regulatory T …

Regulatory T (Treg) cells are a subset of CD 4+ T cells that are critical for the maintenance of
self‐tolerance. The forkhead box transcription factor Foxp3 is a master regulator for the Treg …