Large conductance Ca 2+-and voltage-activated K+(BK) channels are widely distributed in
the postnatal central nervous system (CNS). BK channels play a pleiotropic role in …

Drosophila melanogaster has become a significant model organism for alcohol research. In
flies, a rich variety of behaviors can be leveraged for identifying genes affecting alcohol …

The underlying genetic and epigenetic mechanisms driving functional adaptations in
neuronal excitability and excessive alcohol intake are poorly understood. Small …

Ethanol alters BK (slo1) channel function leading to perturbation of physiology and behavior.
Site (s) and mechanism (s) of ethanol–BK channel interaction are unknown. We …

Alcohol use disorder (AUD) exacts an immense toll on individuals, families, and society.
Genetic factors determine up to 60% of an individual's risk of developing problematic alcohol …

Alcohol abuse is a significant public health problem. Understanding the molecular effects of
ethanol is important for the identification of at risk individuals, as well as the development of …

Sustained or repeated exposure to sedating drugs, such as alcohol, triggers homeostatic
adaptations in the brain that lead to the development of drug tolerance and dependence …

In most tissues, the function of Ca2+-and voltage-gated K+ (BK) channels is modified in
response to ethanol concentrations reached in human blood during alcohol intoxication. In …

The large-conductance K+ channel (BK channel) can control neural excitability, and
enhanced channel currents facilitate high firing rates in cortical neurons. The brain-specific …

Alcohol (ethanol) dependence is a chronic relapsing brain disorder partially influenced by
genetics and characterized by an inability to regulate harmful levels of drinking. Emerging …