The role of the microtubule cytoskeleton in neurodevelopmental disorders
M Lasser, J Tiber, LA Lowery - Frontiers in cellular neuroscience, 2018 - frontiersin.org
Neurons depend on the highly dynamic microtubule (MT) cytoskeleton for many different
processes during early embryonic development including cell division and migration …
processes during early embryonic development including cell division and migration …
Neuronal migration disorders: focus on the cytoskeleton and epilepsy
MA Stouffer, JA Golden, F Francis - Neurobiology of disease, 2016 - Elsevier
A wide spectrum of focal, regional, or diffuse structural brain abnormalities, collectively
known as malformations of cortical development (MCDs), frequently manifest with …
known as malformations of cortical development (MCDs), frequently manifest with …
The α-Tubulin gene TUBA1A in Brain Development: A Key Ingredient in the Neuronal Isotype Blend
J Aiken, G Buscaglia, EA Bates, JK Moore - Journal of developmental …, 2017 - mdpi.com
Microtubules are dynamic cytoskeletal polymers that mediate numerous, essential functions
such as axon and dendrite growth and neuron migration throughout brain development. In …
such as axon and dendrite growth and neuron migration throughout brain development. In …
Mutations in α-and β-tubulin encoding genes: implications in brain malformations
R Romaniello, F Arrigoni, MT Bassi, R Borgatti - Brain and Development, 2015 - Elsevier
The tubulin gene family is mainly expressed in post-mitotic neurons during cortical
development with a specific spatial and temporal expression pattern. Members of this family …
development with a specific spatial and temporal expression pattern. Members of this family …
Neuronal splicing regulator RBFOX3 (NeuN) regulates adult hippocampal neurogenesis and synaptogenesis
Dysfunction of RBFOX3 has been identified in neurodevelopmental disorders such as
autism spectrum disorder, cognitive impairments and epilepsy and a causal relationship with …
autism spectrum disorder, cognitive impairments and epilepsy and a causal relationship with …
Insights on the role of α-and β-tubulin isotypes in early brain development
MSA Tantry, K Santhakumar - Molecular Neurobiology, 2023 - Springer
Tubulins are the highly conserved subunit of microtubules which involve in various
fundamental functions including brain development. Microtubules help in neuronal …
fundamental functions including brain development. Microtubules help in neuronal …
Microtubules and neurodevelopmental disease: the movers and the makers
The development of the mammalian cortex requires the generation, migration and
differentiation of neurons. Each of these cellular events requires a dynamic microtubule …
differentiation of neurons. Each of these cellular events requires a dynamic microtubule …
Mutations in Vps15 perturb neuronal migration in mice and are associated with neurodevelopmental disease in humans
T Gstrein, A Edwards, A Přistoupilová, I Leca… - Nature …, 2018 - nature.com
The formation of the vertebrate brain requires the generation, migration, differentiation and
survival of neurons. Genetic mutations that perturb these critical cellular events can result in …
survival of neurons. Genetic mutations that perturb these critical cellular events can result in …
Bridging the gap: The importance of TUBA1A α-tubulin in forming midline commissures
G Buscaglia, KR Northington, J Aiken… - Frontiers in Cell and …, 2022 - frontiersin.org
Developing neurons undergo dramatic morphological changes to appropriately migrate and
extend axons to make synaptic connections. The microtubule cytoskeleton, made of α/β …
extend axons to make synaptic connections. The microtubule cytoskeleton, made of α/β …
Brain malformations and mutations in α‐ and β‐tubulin genes: a review of the literature and description of two new cases
R Romaniello, F Arrigoni, A Cavallini… - … Medicine & Child …, 2014 - Wiley Online Library
Aim The aim of this study was to determine the frequency of mutations in tubulin genes
(TUBB 2B, TUBA 1A, and TUBB 3) in patients with malformations of cortical development …
(TUBB 2B, TUBA 1A, and TUBB 3) in patients with malformations of cortical development …