Neurons depend on the highly dynamic microtubule (MT) cytoskeleton for many different
processes during early embryonic development including cell division and migration …

A wide spectrum of focal, regional, or diffuse structural brain abnormalities, collectively
known as malformations of cortical development (MCDs), frequently manifest with …

Microtubules are dynamic cytoskeletal polymers that mediate numerous, essential functions
such as axon and dendrite growth and neuron migration throughout brain development. In …

The tubulin gene family is mainly expressed in post-mitotic neurons during cortical
development with a specific spatial and temporal expression pattern. Members of this family …

Dysfunction of RBFOX3 has been identified in neurodevelopmental disorders such as
autism spectrum disorder, cognitive impairments and epilepsy and a causal relationship with …

Tubulins are the highly conserved subunit of microtubules which involve in various
fundamental functions including brain development. Microtubules help in neuronal …

The development of the mammalian cortex requires the generation, migration and
differentiation of neurons. Each of these cellular events requires a dynamic microtubule …

The formation of the vertebrate brain requires the generation, migration, differentiation and
survival of neurons. Genetic mutations that perturb these critical cellular events can result in …

Developing neurons undergo dramatic morphological changes to appropriately migrate and
extend axons to make synaptic connections. The microtubule cytoskeleton, made of α/β …

Aim The aim of this study was to determine the frequency of mutations in tubulin genes
(TUBB 2B, TUBA 1A, and TUBB 3) in patients with malformations of cortical development …