Rapid advances in genomics have opened unprecedented possibilities to explore the
mutational landscapes in malignant diseases, such as B-cell acute lymphoblastic leukemia …

Zinc (Zn) is an essential nutrient required for cell growth, differentiation, and survival, and its
deficiency causes growth retardation, immunodeficiency, and other health problems …

The Philadelphia chromosome, a chromosomal abnormality that encodes BCR–ABL1, is the
defining lesion of chronic myelogenous leukaemia (CML) and a subset of acute …

Background Common variable immunodeficiency (CVID) is characterized by late-onset
hypogammaglobulinemia in the absence of predisposing factors. The genetic cause is …

Despite an increase in survival for children with acute lymphoblastic leukemia (ALL), the
outcome after relapse is poor. To understand the genetic events that contribute to relapse …

Alternative pre‐mRNA splicing leads to distinct products of gene expression in development
and disease. Antagonistic splice variants of genes involved in differentiation, apoptosis …

The BCR-ABL1 fusion gene defines the subgroup of acute lymphoblastic leukemia (ALL)
with the worst clinical prognosis. To identify oncogenic lesions that combine with BCR-ABL1 …

Here we show that the lymphoid lineage-determining factors Ikaros and Aiolos can function
as strong transcriptional repressors. This function is mediated through two repression …

Ikaros is a sequence-specific DNA-binding protein that is essential for lymphocyte
development. Little is known about the molecular function of Ikaros, although recent results …

Ikaros, Aiolos and Helios encode zinc finger transcription factors that are important
regulators of lymphoid development and differentiation. These proteins are involved in the …