Gene regulatory network inference in the era of single-cell multi-omics
P Badia-i-Mompel, L Wessels, S Müller-Dott… - Nature Reviews …, 2023 - nature.com
The interplay between chromatin, transcription factors and genes generates complex
regulatory circuits that can be represented as gene regulatory networks (GRNs). The study …
regulatory circuits that can be represented as gene regulatory networks (GRNs). The study …
Gene regulatory network reconstruction: harnessing the power of single-cell multi-omic data
Inferring gene regulatory networks (GRNs) is a fundamental challenge in biology that aims
to unravel the complex relationships between genes and their regulators. Deciphering these …
to unravel the complex relationships between genes and their regulators. Deciphering these …
Leveraging multimodal chromatin profiling to identify a new potential driver of diabetic kidney disease
Y Muto, BD Humphreys - Kidney International, 2024 - Elsevier
The 3-dimensional nature of chromatin architecture plays crucial roles in regulating gene
expression in development, homeostasis, and disease. Until recently, however …
expression in development, homeostasis, and disease. Until recently, however …
[HTML][HTML] Gene regulatory network inference with popInfer reveals dynamic regulation of hematopoietic stem cell quiescence upon diet restriction and aging
MK Rommelfanger, M Behrends, Y Chen, J Martinez… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Inference of gene regulatory networks (GRNs) can reveal cell state transitions from single-
cell genomics data. However, obstacles to temporal inference from snapshot data are …
cell genomics data. However, obstacles to temporal inference from snapshot data are …
[HTML][HTML] Epigenetic reprogramming driving successful and failed repair in acute kidney injury
Y Muto, EE Dixon, Y Yoshimura, N Ledru, Y Kirita… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Acute kidney injury (AKI) causes epithelial damage followed by subsequent repair. While
successful repair restores kidney function, this process is often incomplete and can lead to …
successful repair restores kidney function, this process is often incomplete and can lead to …