COVID-19 and diabetes mellitus: from pathophysiology to clinical management
Initial studies found increased severity of coronavirus disease 2019 (COVID-19), caused by
infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), in patients …
infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), in patients …
Angiotensin II signal transduction: an update on mechanisms of physiology and pathophysiology
The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …
Two important controversial risk factors in SARS-CoV-2 infection: obesity and smoking
The effects of obesity and smoking in the coronavirus disease 2019 (COVID-19) pandemic
remain controversial. Angiotensin converting enzyme 2 (ACE2), a component of the renin …
remain controversial. Angiotensin converting enzyme 2 (ACE2), a component of the renin …
Diabetes, oxidative stress and therapeutic strategies
L Rochette, M Zeller, Y Cottin, C Vergely - Biochimica et Biophysica Acta …, 2014 - Elsevier
Background Diabetes has emerged as a major threat to health worldwide. Scope of Review
The exact mechanisms underlying the disease are unknown; however, there is growing …
The exact mechanisms underlying the disease are unknown; however, there is growing …
Nitric oxide synthase inhibition and oxidative stress in cardiovascular diseases: possible therapeutic targets?
L Rochette, J Lorin, M Zeller, JC Guilland… - Pharmacology & …, 2013 - Elsevier
Nitric oxide (radical dot NO) is synthetized enzymatically from l-arginine (l-Arg) by three NO
synthase isoforms, iNOS, eNOS and nNOS. The synthesis of NO is selectively inhibited by …
synthase isoforms, iNOS, eNOS and nNOS. The synthesis of NO is selectively inhibited by …
[HTML][HTML] The renin angiotensin system, oxidative stress and mitochondrial function in obesity and insulin resistance
Obesity is a complex disease characterized by excessive expansion of adipose tissue and is
an important risk factor for chronic diseases such as cardiovascular disorders, hypertension …
an important risk factor for chronic diseases such as cardiovascular disorders, hypertension …
Renoprotective mechanisms of sodium‐glucose co‐transporter 2 (SGLT2) inhibitors against the progression of diabetic kidney disease
S Ravindran, S Munusamy - Journal of cellular physiology, 2022 - Wiley Online Library
Sodium‐glucose co‐transporter 2 inhibitors (SGLT2‐Is) have emerged as a promising class
of antidiabetic drugs with cardioprotective and renoprotective effects in patients with type 2 …
of antidiabetic drugs with cardioprotective and renoprotective effects in patients with type 2 …
The renin angiotensin aldosterone system and insulin resistance in humans
PC Underwood, GK Adler - Current hypertension reports, 2013 - Springer
Alterations in the renin angiotensin aldosterone system (RAAS) contribute to the underlying
pathophysiology of insulin resistance in humans; however, individual differences in the …
pathophysiology of insulin resistance in humans; however, individual differences in the …
Molecular and metabolic mechanisms of cardiac dysfunction in diabetes
CH Mandavia, AR Aroor, VG DeMarco, JR Sowers - Life sciences, 2013 - Elsevier
Diabetes mellitus type 2 (T2DM) is a widespread chronic medical condition with prevalence
bordering on the verge of an epidemic. It is of great concern that cardiovascular disease is …
bordering on the verge of an epidemic. It is of great concern that cardiovascular disease is …
Link between the renin–angiotensin system and insulin resistance: Implications for cardiovascular disease
MS Zhou, IH Schulman, Q Zeng - Vascular medicine, 2012 - journals.sagepub.com
The incidence of metabolic syndrome is rapidly increasing in the United States and
worldwide. The metabolic syndrome is a complex metabolic and vascular disorder that is …
worldwide. The metabolic syndrome is a complex metabolic and vascular disorder that is …