Inactivity-induced phrenic motor facilitation requires PKCζ activity within phrenic motor neurons

NA Baertsch, AB Marciante… - Journal of …, 2024 - journals.physiology.org
Prolonged inhibition of respiratory neural activity elicits a long-lasting increase in phrenic
nerve amplitude, known as inactivity-induced phrenic motor facilitation (iPMF). Facilitation …

[HTML][HTML] Microglia regulate motor neuron plasticity via reciprocal fractalkine/adenosine signaling

AB Marciante, A Tadjalli, KA Burrowes, JR Oberto… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Microglia are innate CNS immune cells that play key roles in supporting key CNS functions
including brain plasticity. We now report a previously unknown role for microglia in …

Time of day does not impact spinal serotonin levels in humans

SK Anand, RS Lavadi, BR Johnston, JI Chalif… - Synapse, 2024 - Wiley Online Library
Spinal serotonin enables neuro‐motor recovery (ie, plasticity) in patients with debilitating
paralysis. While there exists time of day fluctuations in serotonin‐dependent spinal plasticity …

Temporal Dynamics and Therapeutic Implications of Phrenic Long-Term Facilitation in Respiratory Control

H Bhagavan, NJ Burgraff, JM Ramirez - Function, 2024 - academic.oup.com
Breathing is an autonomic function essential for life, yet it functions with a remarkable
capacity for adaptive changes. 1, 2 Notably, the respiratory control system, specifically the …