Reactive oxygen species (ROS), superoxide anion and hydrogen peroxide, are generated
as byproducts of oxidative phosphorylation in the mitochondria or via cell signaling-induced …

Cellular metabolism in hematopoietic stem cells (HSCs) is an area of intense research
interest, but the metabolic requirements of HSCs and their adaptations to their niches during …

An appropriate balance between self-renewal and differentiation is crucial for stem cell
function during both early development and tissue homeostasis throughout life. Recent …

Pluripotent stem cells (PSCs) are characterized by their unique capacity for both unlimited
self-renewal and their potential to differentiate to all cell lineages contained within the three …

Long-term survival and antitumor immunity of adoptively transferred CD8+ T cells is
dependent on their metabolic fitness, but approaches to isolate therapeutic T cells based on …

Plasticity in energy metabolism allows stem cells to match the divergent demands of self-
renewal and lineage specification. Beyond a role in energetic support, new evidence …

Recent advances in metabolomics and computational analysis have deepened our
appreciation for the role of specific metabolic pathways in dictating cell fate. Once thought to …

As sites of cellular respiration and energy production, mitochondria play a central role in cell
metabolism. Cell differentiation is associated with an increase in mitochondrial content and …

A considerable amount of knowledge has been produced during the last five years on the
bioenergetics of cancer cells, leading to a better understanding of the regulation of energy …

The ability to quantify differentiation potential of single cells is a task of critical importance.
Here we demonstrate, using over 7,000 single-cell RNA-Seq profiles, that differentiation …