Gestational factors throughout fetal neurodevelopment: the serotonin link

SI Hanswijk, M Spoelder, L Shan, MMM Verheij… - International journal of …, 2020 - mdpi.com
Serotonin (5-HT) is a critical player in brain development and neuropsychiatric disorders.
Fetal 5-HT levels can be influenced by several gestational factors, such as maternal …

An emerging cross-species marker for organismal health: tryptophan-kynurenine pathway

L Jamshed, A Debnath, S Jamshed, JV Wish… - International Journal of …, 2022 - mdpi.com
Tryptophan (TRP) is an essential dietary amino acid that, unless otherwise committed to
protein synthesis, undergoes metabolism via the Tryptophan-Kynurenine (TRP-KYN) …

Serotonin limits generation of chromaffin cells during adrenal organ development

P Kameneva, VI Melnikova, ME Kastriti… - Nature …, 2022 - nature.com
Adrenal glands are the major organs releasing catecholamines and regulating our stress
response. The mechanisms balancing generation of adrenergic chromaffin cells and …

Perinatal infection, inflammation, preterm birth, and brain injury: A review with proposals for future investigations

JD Reiss, LS Peterson, SN Nesamoney, AL Chang… - Experimental …, 2022 - Elsevier
Preterm newborns are exposed to several risk factors for developing brain injury. Clinical
studies have suggested that the presence of intrauterine infection is a consistent risk factor …

The gut-immune-brain axis in autism spectrum disorders; a focus on amino acids

JHJ van Sadelhoff, P Perez Pardo, J Wu… - Frontiers in …, 2019 - frontiersin.org
Autism spectrum disorder (ASD) is a range of neurodevelopmental conditions that affect
communication and social behavior. Besides social deficits, systemic inflammation …

Prenatal inflammation as a link between placental expression signature of tryptophan metabolism and preterm birth

R Karahoda, M Robles, J Marushka… - Human Molecular …, 2021 - academic.oup.com
Spontaneous preterm birth is a serious medical condition responsible for substantial
perinatal morbidity and mortality. Its phenotypic characteristics, preterm labor with intact …

IDO and TDO as a potential therapeutic target in different types of depression

Y Qin, N Wang, X Zhang, X Han, X Zhai, Y Lu - Metabolic brain disease, 2018 - Springer
Depression is highly prevalent worldwide and a leading cause of disabilty. However, the
medications currently available to treat depression fail to adequately relieve depressive …

Maternal stressors and the developmental origins of neuropsychiatric risk

SG Khambadkone, ZA Cordner… - Frontiers in …, 2020 - Elsevier
The maternal environment during pregnancy is critical for fetal development and perinatal
perturbations can prime offspring disease risk. Here, we briefly review evidence linking two …

Analyzing the potential biological determinants of autism spectrum disorder: from neuroinflammation to the kynurenine pathway

R Savino, M Carotenuto, AN Polito, S Di Noia… - Brain sciences, 2020 - mdpi.com
Autism Spectrum Disorder (ASD) etiopathogenesis is still unclear and no effective
preventive and treatment measures have been identified. Research has focused on the …

Models of Intrauterine growth restriction and fetal programming in rabbits

J Lopez‐Tello, M Arias‐Alvarez… - Molecular …, 2019 - Wiley Online Library
Intrauterine growth restriction (IUGR) affects approximately 10% of human pregnancies
globally and has immediate and life‐long consequences for offspring health. However, the …