Long-lived species Homo sapiens have evolved robust protection mechanisms against
cancer by repressing telomerase and maintaining short telomeres, thereby delaying the …

A G-quadruplex (G4) is a well-known nucleic acid secondary structure comprising guanine-
rich sequences, and has profound implications for various pharmacological and biological …

Telomere maintenance via telomerase reactivation is a nearly universal hallmark of cancer
cells which enables replicative immortality. In contrast, telomerase activity is silenced in most …

The hallmarks of cancer comprise six biological capabilities acquired during the multistep
development of human tumors. The hallmarks constitute an organizing principle for …

The natural ends of linear chromosomes require unique genetic and structural adaptations
to facilitate the protection of genetic material. This is achieved by the sequestration of the …

Myriad genetic and epigenetic alterations are required to drive normal cells toward
malignant transformation. These somatic events commandeer many signaling pathways that …

Stem cells are controlled, in part, by genetic pathways frequently dysregulated during
human tumorigenesis. Either stimulation of Wnt/β-catenin signalling or overexpression of …

Although elongation of telomeres is thought to be the prime function of reactivated
telomerase in cancers, this activity alone does not account for all of the properties that …

Estrogen, progesterone, and HER2 receptor-negative triple-negative breast cancers
encompass the most clinically challenging subtype for which targeted therapeutics are …

Although human atherosclerosis is associated with aging, direct evidence of cellular
senescence and the mechanism of senescence in vascular smooth muscle cells (VSMCs) in …