Nano-based approved pharmaceuticals for cancer treatment: present and future challenges

F Rodríguez, P Caruana, N De la Fuente, P Español… - Biomolecules, 2022 - mdpi.com
Cancer is one of the main causes of death worldwide. To date, and despite the advances in
conventional treatment options, therapy in cancer is still far from optimal due to the non …

Exploring the promising potential of induced pluripotent stem cells in cancer research and therapy

M Chehelgerdi, F Behdarvand Dehkordi… - Molecular Cancer, 2023 - Springer
The advent of iPSCs has brought about a significant transformation in stem cell research,
opening up promising avenues for advancing cancer treatment. The formation of cancer is a …

Advancement in precision diagnosis and therapeutic for triple-negative breast cancer: Harnessing diagnostic potential of CRISPR-cas & engineered CAR T-cells …

V Nayak, S Patra, KRB Singh, B Ganguly… - Environmental …, 2023 - Elsevier
Cancer is characterized by uncontrolled cell growth, disrupted regulatory pathways, and the
accumulation of genetic mutations. These mutations across different types of cancer lead to …

Magnetic nanoparticle-based hyperthermia: A prospect in cancer stem cell tracking and therapy

P Montazersaheb, E Pishgahzadeh, VB Jahani… - Life Sciences, 2023 - Elsevier
Tumor heterogeneity is a major problem in cancer treatment. Cancer stem cells (CSCs) are
a subpopulation of tumor masses that produce proliferating and quiescent cells. Under …

Cellular activation pathways and interaction networks in vascularized composite allotransplantation

L Knoedler, S Knoedler, AC Panayi, CAA Lee… - Frontiers in …, 2023 - frontiersin.org
Vascularized composite allotransplantation (VCA) is an evolving field of reconstructive
surgery that has revolutionized the treatment of patients with devastating injuries, including …

Li-doped bioactive ceramics: promising biomaterials for tissue engineering and regenerative medicine

AR Farmani, MA Salmeh, Z Golkar… - Journal of Functional …, 2022 - mdpi.com
Lithium (Li) is a metal with critical therapeutic properties ranging from the treatment of
bipolar depression to antibacterial, anticancer, antiviral and pro-regenerative effects. This …

Innovation in cancer therapeutics and regulatory perspectives

P Sharma, V Jhawat, P Mathur, R Dutt - Medical oncology, 2022 - Springer
Cancer therapy has undergone a drastic revolution in the past few decades with the
introduction of several novel therapies, like immunotherapy (active and passive), stem cell …

The role of mesenchymal stem cells derived exosomes as a novel nanobiotechnology target in the diagnosis and treatment of cancer

Y Zhou, Y Dong, A Zhang, J Wu, Q Sun - Frontiers in Bioengineering …, 2023 - frontiersin.org
Mesenchymal stem cells (MSCs), one of the most common types of stem cells, are involved
in the modulation of the tumor microenvironment (TME). With the advancement of …

Applications for Colon Organoid Models in Cancer Research

MJ Munro, ST Tan, C Gray - Organoids, 2023 - mdpi.com
Organoids are 3D organ-like structures grown from stem cells in vitro that mimic the organ or
disease from which they are derived. Due to their stem cell origin, organoids contain a …

Modeling preclinical cancer studies under physioxia to enhance clinical translation

AK Adebayo, H Nakshatri - Cancer research, 2022 - AACR
Oxygen (O2) plays a key role in cellular homeostasis. O2 levels are tightly regulated in vivo
such that each tissue receives an optimal amount to maintain physiologic status. Physiologic …