The distinct prion-like domains (PrLDs) of FUS and TDP-43, modulate phase transitions that
result in condensates with a range of material states. These assemblies are implicated in …

Gene expression programmes conferring cellular identity are achieved through the
organization of chromatin structures that either facilitate or impede transcription. Among the …

Transcriptional memory is characterized by a primed cellular state, induced by an external
stimulus that results in an altered expression of primed genes upon re-exposure to the …

The current evolutionary biology theory primarily involves genetic alterations and random
DNA sequence mutations to generate the phenotypic variation required for Darwinian …

Heterochromatin that depends on histone H3 lysine 9 methylation (H3K9me) renders
embedded genes transcriptionally silent,–. In the fission yeast Schizosaccharomyces …

The cellular machinery that regulates gene expression can be self-propagated across cell
division cycles and even generations. This renders gene expression states and their …

If genetics defines the inheritance of DNA, epigenetics aims to regulate and make it
adaptable. Epigenetic alterations include DNA methylation, chromatin remodelling, post …

Prion diseases are transmissible spongiform encephalopathies (TSEs) caused by a
conformational conversion of the native cellular prion protein (PrPC) to an abnormal …

Some epigenetic information can be transmitted between generations without changes in
the underlying DNA sequence. Changes in epigenetic regulators, termed epimutations, can …

Prions are self‐perpetuating proteins able to switch between a soluble state and an
aggregated‐and‐transmissible conformation. These proteinaceous entities have been …