The dynamics of gut‐associated microbial communities during inflammation
SE Winter, CA Lopez, AJ Bäumler - EMBO reports, 2013 - embopress.org
Our intestine is host to a large microbial community (microbiota) that educates the immune
system and confers niche protection. Profiling of the gut‐associated microbial community …
system and confers niche protection. Profiling of the gut‐associated microbial community …
Glutathione: Role in oxidative/nitrosative stress, antioxidant defense, and treatments
S Raj Rai, C Bhattacharyya, A Sarkar… - …, 2021 - Wiley Online Library
Glutathione (GSH) is the most abundant cellular tripeptide (L‐γ‐glutamate‐L‐cysteinyl‐
glycine) which is as critical as oxygen and water. This low molecular mass antioxidant has a …
glycine) which is as critical as oxygen and water. This low molecular mass antioxidant has a …
Effects of nitric oxide synthase inhibitors on murine infection with Mycobacterium tuberculosis
J Chan, K Tanaka, D Carroll, J Flynn… - Infection and …, 1995 - Am Soc Microbiol
We have recently demonstrated that the macrophage L-arginine-dependent cytotoxic
pathway effectively kills the virulent Erdman strain of Mycobacterium tuberculosis in vitro via …
pathway effectively kills the virulent Erdman strain of Mycobacterium tuberculosis in vitro via …
Human M1 macrophages express unique innate immune response genes after mycobacterial infection to defend against tuberculosis
Mycobacterium tuberculosis (Mtb) is responsible for approximately 1.5 million deaths each
year. Though 10% of patients develop tuberculosis (TB) after infection, 90% of these …
year. Though 10% of patients develop tuberculosis (TB) after infection, 90% of these …
Glutathione and infection
BACKGROUND: The tripeptide γ-glutamylcysteinylglycine or glutathione (GSH) has
demonstrated protective abilities against the detrimental effects of oxidative stress within the …
demonstrated protective abilities against the detrimental effects of oxidative stress within the …
What is the role of nitric oxide in murine and human host defense against tuberculosis? Current knowledge
ED Chan, J Chan, NW Schluger - American journal of respiratory …, 2001 - atsjournals.org
The production of reactive oxygen intermediates and reactive nitrogen intermediates by
innate immune cells is considered to be an effective host-defense mechanism against …
innate immune cells is considered to be an effective host-defense mechanism against …
Disruption of the Genes Encoding Antigen 85A and Antigen 85B ofMycobacterium tuberculosis H37Rv: Effect on Growth in Culture and in Macrophages
LY Armitige, C Jagannath, AR Wanger… - Infection and …, 2000 - Am Soc Microbiol
The mechanism of pathogenesis of Mycobacterium tuberculosis is thought to be
multifactorial. Among the putative virulence factors is the antigen 85 (Ag85) complex. This …
multifactorial. Among the putative virulence factors is the antigen 85 (Ag85) complex. This …
The Inducible Nitric Oxide Synthase Locus Confers Protection against Aerogenic Challenge of Both Clinical and Laboratory Strains of Mycobacterium tuberculosis in …
Murine macrophages effect potent antimycobacterial function via the production of nitric
oxide by the inducible isoform of the enzyme nitric oxide synthase (NOS2). The protective …
oxide by the inducible isoform of the enzyme nitric oxide synthase (NOS2). The protective …
[HTML][HTML] The many faces of host responses to tuberculosis
HL Collins, SHE Kaufmann - Immunology, 2001 - ncbi.nlm.nih.gov
Tuberculosis remains today one of the top three fatal infectious diseases, together with
acquired immune deficiency syndrome (AIDS) and malaria. During the last decade, 90 …
acquired immune deficiency syndrome (AIDS) and malaria. During the last decade, 90 …
On the killing of mycobacteria by macrophages
Both pathogenic and non‐pathogenic mycobacteria are internalized into macrophage
phagosomes. Whereas the non‐pathogenic types are invariably killed by all macrophages …
phagosomes. Whereas the non‐pathogenic types are invariably killed by all macrophages …