RNA–DNA hybrids are generated during transcription, DNA replication and DNA repair and
are crucial intermediates in these processes. When RNA–DNA hybrids are stably formed in …

Although transcription is an essential cellular process, it is paradoxically also a well-
recognized cause of genomic instability. R-loops, non-B DNA structures formed when …

During transcription, the nascent RNA strand can base pair with its template DNA, displacing
the non-template strand as ssDNA and forming a structure called an R-loop. R-loops are …

Soft tissue sarcomas (STS) are rare and diverse mesenchymal cancers with limited
treatment options. Here we undertake comprehensive proteomic profiling of tumour …

Multi-subunit ATPase-dependent chromatin remodelling complexes SWI/SNF
(switch/sucrose non-fermentable) are fundamental epigenetic regulators of gene …

PARP inhibitors (PARPis) have clinical efficacy in BRCA-deficient cancers, but not BRCA-
intact tumors, including glioblastoma (GBM). We show that MYC or MYCN amplification in …

ARID1A is a core DNA-binding subunit of the BAF chromatin remodeling complex, and is
lost in up to 7% of all cancers. The frequency of ARID1A loss increases in certain cancer …

The response to DNA replication stress in eukaryotes is under the control of the ataxia–
telangiectasia and Rad3-related (ATR) kinase. ATR responds to single-stranded (ss) DNA to …

Introduction: Defects in the DNA damage response (DDR) drive the development of cancer
by fostering DNA mutation but also provide cancer-specific vulnerabilities that can be …

Opinion Statement Synovial sarcoma (SS) is a rare, yet highly malignant, type of soft tissue
sarcoma (STS), for which survival has not improved significantly during the past years. In this …