AgRP/NPY and POMC neurons in the arcuate nucleus and their potential role in treatment of obesity

MS Vohra, K Benchoula, CJ Serpell, WE Hwa - European journal of …, 2022 - Elsevier
Obesity is a major health crisis affecting over a third of the global population. This
multifactorial disease is regulated via interoceptive neural circuits in the brain, whose …

Recent advances in research on polyphenols: effects on microbiota, metabolism, and health

HN Rajha, A Paule, G Aragonès… - Molecular Nutrition & …, 2022 - Wiley Online Library
Polyphenols have attracted huge interest among researchers of various disciplines because
of their numerous biological activities, such as antioxidative, antiinflammatory, antiapoptotic …

Effects of dietary grape seed proanthocyanidin extract supplementation on meat quality, muscle fiber characteristics and antioxidant capacity of finishing pigs

M Xu, X Chen, Z Huang, D Chen, M Li, J He, H Chen… - Food Chemistry, 2022 - Elsevier
The aim of this study was to investigate effects of dietary grape seed proanthocyanidin
extract (GSPE) supplementation on meat quality, muscle fiber characteristics and antioxidant …

Leptin and nutrition in gestational diabetes

A Pérez-Pérez, T Vilariño-García, P Guadix, JL Dueñas… - Nutrients, 2020 - mdpi.com
Leptin is highly expressed in the placenta, mainly by trophoblastic cells, where it has an
important autocrine trophic effect. Moreover, increased leptin levels are found in the most …

Rethinking the mechanism of the health benefits of proanthocyanidins: Absorption, metabolism, and interaction with gut microbiota

W Tao, Y Zhang, X Shen, Y Cao, J Shi… - … Reviews in Food …, 2019 - Wiley Online Library
Proanthocyanidins, as the oligomers or polymers of flavan‐3‐ol, are widely discovered in
plants such as fruits, vegetables, cereals, nuts, and leaves, presenting a major part of dietary …

Health benefits of proanthocyanidins linking with gastrointestinal modulation: An updated review

X Zhang, X Song, X Hu, F Chen, C Ma - Food Chemistry, 2023 - Elsevier
Proanthocyanidins (PACs) are the bioactive components naturally present in daily diet,
especially in fruits and vegetables. Multiple pieces of evidence suggested that ingestion of …

The evidence of metabolic-improving effect of metformin in Ay/a mice with genetically-induced melanocortin obesity and the contribution of hypothalamic mechanisms …

K Derkach, I Zakharova, I Zorina, A Bakhtyukov… - PLoS …, 2019 - journals.plos.org
In diet-induced obesity, metformin (MF) has weight-lowering effect and improves glucose
homeostasis and insulin sensitivity. However, there is no information on the efficiency of MF …

Pancreatic lipase and α-amylase inhibitory activity of extracts from selected plant materials after gastrointestinal digestion in vitro

J Siegień, T Buchholz, D Popowski, S Granica… - Food Chemistry, 2021 - Elsevier
A screening of inhibitory activity of α-amylase, as well as pancreatic lipase (PL), under the
influence of aqueous and ethanolic preparations from 12 plant materials was performed …

Dietary polyphenols to combat nonalcoholic fatty liver disease via the gut–brain–liver axis: a review of possible mechanisms

Z Wang, M Zeng, Z Wang, F Qin… - Journal of Agricultural …, 2021 - ACS Publications
Polyphenols are a group of micronutrients widely existing in plant foods including fruits,
vegetables, and teas that can improve nonalcoholic fatty liver disease (NAFLD). In this …

[HTML][HTML] Effects of grape seed proanthocyanidin extract on obesity

M Liu, P Yun, Y Hu, J Yang, RB Khadka, X Peng - Obesity Facts, 2020 - karger.com
Obesity is a chronic metabolic disease resulting from excessive fat accumulation and/or
abnormal distribution caused by multiple factors. As a major component of metabolic …