Polymeric delivery of therapeutic nucleic acids
R Kumar, CF Santa Chalarca, MR Bockman… - Chemical …, 2021 - ACS Publications
The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …
Understanding nanomaterial–liver interactions to facilitate the development of safer nanoapplications
Nanomaterials (NMs) are widely used in commercial and medical products, such as
cosmetics, vaccines, and drug carriers. Exposure to NMs via various routes such as dermal …
cosmetics, vaccines, and drug carriers. Exposure to NMs via various routes such as dermal …
Polyplex designs for improving the stability and safety of RNA therapeutics
Nanoparticle-based delivery systems have contributed to the recent clinical success of RNA
therapeutics, including siRNA and mRNA. RNA delivery using polymers has several distinct …
therapeutics, including siRNA and mRNA. RNA delivery using polymers has several distinct …
Core polymer optimization of ternary siRNA nanoparticles enhances in vivo safety, pharmacokinetics, and tumor gene silencing
Gene silencing with siRNA nanoparticles (si-NPs) is promising but still clinically unrealized
for inhibition of tumor driver genes. Ternary si-NPs containing siRNA, a single block NP core …
for inhibition of tumor driver genes. Ternary si-NPs containing siRNA, a single block NP core …
Therapeutic RNA delivery for COVID and other diseases
RNA can alter the expression of endogenous genes and can be used to express therapeutic
proteins. As a result, RNA‐based therapies have recently mitigated disease in patients. Yet …
proteins. As a result, RNA‐based therapies have recently mitigated disease in patients. Yet …
Stimulating TAM-mediated anti-tumor immunity with mannose-decorated nanoparticles in ovarian cancer
EB Glass, AA Hoover, KK Bullock, MZ Madden… - BMC cancer, 2022 - Springer
Background Current cancer immunotherapies have made tremendous impacts but generally
lack high response rates, especially in ovarian cancer. New therapies are needed to provide …
lack high response rates, especially in ovarian cancer. New therapies are needed to provide …
Optimizing an Antioxidant TEMPO Copolymer for Reactive Oxygen Species Scavenging and Anti-Inflammatory Effects in Vivo
Oxidative stress is broadly implicated in chronic, inflammatory diseases because it causes
protein and lipid damage, cell death, and stimulation of inflammatory signaling …
protein and lipid damage, cell death, and stimulation of inflammatory signaling …
PEGylated polyester nanoparticles trigger adverse events in a large animal model of Trauma and in Naı̈ve animals: understanding Cytokine and Cellular …
Intravenously infusible nanoparticles to control bleeding have shown promise in rodents, but
translation into preclinical models has been challenging as many of these nanoparticle …
translation into preclinical models has been challenging as many of these nanoparticle …
Structural optimization of siRNA conjugates for albumin binding achieves effective MCL1-directed cancer therapy
EN Hoogenboezem, SS Patel, JH Lo… - Nature …, 2024 - nature.com
The high potential of siRNAs to silence oncogenic drivers remains largely untapped due to
the challenges of tumor cell delivery. Here, divalent lipid-conjugated siRNAs are optimized …
the challenges of tumor cell delivery. Here, divalent lipid-conjugated siRNAs are optimized …
Replacement of L-amino acid peptides with D-amino acid peptides mitigates anti-PEG antibody generation against polymer-peptide conjugates in mice
The generation of anti-PEG antibodies in response to PEGylated proteins, peptides, and
carriers significantly limits their clinical applicability. IgM antibodies mediate the clearance of …
carriers significantly limits their clinical applicability. IgM antibodies mediate the clearance of …