Work over the last decade has uncovered a new layer of epigenetic dysregulation. It is now
appreciated that somatic missense mutations in histones, the packaging agents of genomic …

Epigenetic alterations are associated with normal biological processes such as aging or
differentiation. Changes in global epigenetic signatures, together with genetic alterations …

Background The oncogenic role of histone mutations is one of the most relevant discovery in
cancer epigenetics. Recurrent mutations targeting histone genes have been described in …

Genes encoding histone proteins are recurrently mutated in tumor samples, and these
mutations may impact nucleosome stability, histone post-translational modification, or …

Cancer is a complex pathology that causes a large number of deaths worldwide. Several
risk factors are involved in tumor transformation, including epigenetic factors. These factors …

Neoadjuvant denosumab is highly effective for advanced GCTB, and a short-course is
advised to facilitate surgery, whereas increased recurrence rates remain of concern …

Since the discovery of recurrent mutations in histone H3 variants in paediatric brain tumours,
so‐called 'oncohistones' have been identified in various cancers. While their mechanism of …

Abstract Mutations in histone H3. 3‐encoding genes causing mutant histone tails are
associated with specific cancers such as pediatric glioblastomas (H3. 3‐G34R/V) and giant …

Identification of mutations in histones in a number of human neoplasms and developmental
syndromes represents the most compelling evidence to date for a causal role of epigenetic …

The 2021 World Health Organization Classification of Tumors of the Central Nervous System
reflected advances in understanding of the roles of oncohistones in gliomagenesis with the …