[HTML][HTML] ACE2/ADAM17/TMPRSS2 interplay may be the main risk factor for COVID-19
D Zipeto, JF Palmeira, GA Argañaraz… - Frontiers in …, 2020 - frontiersin.org
The Coronavirus Disease 2019 (COVID-19) has already caused hundreds of thousands of
deaths worldwide in a few months. Cardiovascular disease, hypertension, diabetes and …
deaths worldwide in a few months. Cardiovascular disease, hypertension, diabetes and …
[HTML][HTML] The tissue inhibitors of metalloproteinases (TIMPs): an ancient family with structural and functional diversity
K Brew, H Nagase - Biochimica et biophysica acta (BBA)-molecular cell …, 2010 - Elsevier
Tissue inhibitors of metalloproteinases (TIMPs) are widely distributed in the animal kingdom
and the human genome contains four paralogous genes encoding TIMPs 1 to 4. TIMPs were …
and the human genome contains four paralogous genes encoding TIMPs 1 to 4. TIMPs were …
Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment
J Amar, C Chabo, A Waget, P Klopp… - EMBO molecular …, 2011 - embopress.org
A fat‐enriched diet modifies intestinal microbiota and initiates a low‐grade inflammation,
insulin resistance and type‐2 diabetes. Here, we demonstrate that before the onset of …
insulin resistance and type‐2 diabetes. Here, we demonstrate that before the onset of …
Metabolic adaptation to a high-fat diet is associated with a change in the gut microbiota
M Serino, E Luche, S Gres, A Baylac, M Bergé… - Gut, 2012 - gut.bmj.com
Objective The gut microbiota, which is considered a causal factor in metabolic diseases as
shown best in animals, is under the dual influence of the host genome and nutritional …
shown best in animals, is under the dual influence of the host genome and nutritional …
TLR4 at the crossroads of nutrients, gut microbiota, and metabolic inflammation
Obesity is accompanied by the activation of low-grade inflammatory activity in metabolically
relevant tissues. Studies have shown that obesity-associated insulin resistance results from …
relevant tissues. Studies have shown that obesity-associated insulin resistance results from …
[HTML][HTML] Strategies to target ADAM17 in disease: from its discovery to the iRhom revolution
M Calligaris, D Cuffaro, S Bonelli, DP Spanò… - Molecules, 2021 - mdpi.com
For decades, disintegrin and metalloproteinase 17 (ADAM17) has been the object of deep
investigation. Since its discovery as the tumor necrosis factor convertase, it has been …
investigation. Since its discovery as the tumor necrosis factor convertase, it has been …
MicroRNA 217 modulates endothelial cell senescence via silent information regulator 1
R Menghini, V Casagrande, M Cardellini, E Martelli… - Circulation, 2009 - Am Heart Assoc
Background—Aging is a major risk factor for the development of atherosclerosis and
coronary artery disease. Through a microarray approach, we have identified a microRNA …
coronary artery disease. Through a microarray approach, we have identified a microRNA …
Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17
CD Chen, S Podvin, E Gillespie… - Proceedings of the …, 2007 - National Acad Sciences
Cleavage and release (shedding) of membrane proteins is a critical regulatory step in many
normal and pathological processes. Evidence suggests that the antiaging transmembrane …
normal and pathological processes. Evidence suggests that the antiaging transmembrane …
[HTML][HTML] The role of gut microbiota on insulin resistance
AM Caricilli, MJA Saad - Nutrients, 2013 - mdpi.com
The development of obesity and insulin resistance has been extensively studied in the last
decades, but the mechanisms underlying these alterations are still not completely …
decades, but the mechanisms underlying these alterations are still not completely …
Mechanisms of disease: endothelial dysfunction in insulin resistance and diabetes
C Rask-Madsen, GL King - Nature clinical practice Endocrinology & …, 2007 - nature.com
Endothelial dysfunction is one manifestation of the many changes induced in the arterial
wall by the metabolic abnormalities accompanying diabetes and insulin resistance. In type 1 …
wall by the metabolic abnormalities accompanying diabetes and insulin resistance. In type 1 …