The Coronavirus Disease 2019 (COVID-19) has already caused hundreds of thousands of
deaths worldwide in a few months. Cardiovascular disease, hypertension, diabetes and …

Tissue inhibitors of metalloproteinases (TIMPs) are widely distributed in the animal kingdom
and the human genome contains four paralogous genes encoding TIMPs 1 to 4. TIMPs were …

A fat‐enriched diet modifies intestinal microbiota and initiates a low‐grade inflammation,
insulin resistance and type‐2 diabetes. Here, we demonstrate that before the onset of …

Objective The gut microbiota, which is considered a causal factor in metabolic diseases as
shown best in animals, is under the dual influence of the host genome and nutritional …

Obesity is accompanied by the activation of low-grade inflammatory activity in metabolically
relevant tissues. Studies have shown that obesity-associated insulin resistance results from …

For decades, disintegrin and metalloproteinase 17 (ADAM17) has been the object of deep
investigation. Since its discovery as the tumor necrosis factor convertase, it has been …

Background—Aging is a major risk factor for the development of atherosclerosis and
coronary artery disease. Through a microarray approach, we have identified a microRNA …

Cleavage and release (shedding) of membrane proteins is a critical regulatory step in many
normal and pathological processes. Evidence suggests that the antiaging transmembrane …

The development of obesity and insulin resistance has been extensively studied in the last
decades, but the mechanisms underlying these alterations are still not completely …

Endothelial dysfunction is one manifestation of the many changes induced in the arterial
wall by the metabolic abnormalities accompanying diabetes and insulin resistance. In type 1 …