Targeting carbonic anhydrase IX and XII isoforms with small molecule inhibitors and monoclonal antibodies
Carbonic anhydrases IX and CAXII (CAIX/CAXII) are transmembrane zinc metalloproteins
that catalyze a very basic but crucial physiological reaction: the conversion of carbon dioxide …
that catalyze a very basic but crucial physiological reaction: the conversion of carbon dioxide …
Anticancer therapeutic potential of benzofuran scaffolds
Benzofuran moiety is the main component of many biologically active natural and synthetic
heterocycles. These heterocycles have unique therapeutic potentials and are involved in …
heterocycles. These heterocycles have unique therapeutic potentials and are involved in …
A decade of tail-approach based design of selective as well as potent tumor associated carbonic anhydrase inhibitors
Human carbonic anhydrase (hCA) isoforms hCA IX and hCA XII are well established
anticancer drug targets and their selective inhibition is highly desired for the proper …
anticancer drug targets and their selective inhibition is highly desired for the proper …
Discovery of new carbonic anhydrase IX inhibitors as anticancer agents by toning the hydrophobic and hydrophilic rims of the active site to encounter the dual-tail …
HO Tawfik, A Petreni, CT Supuran… - European journal of …, 2022 - Elsevier
The hydrophobic and the hydrophilic rims in the active site of human carbonic anhydrase IX
(hCA IX) which as well contains a zinc ion as part of the catalytic core, were simultaneously …
(hCA IX) which as well contains a zinc ion as part of the catalytic core, were simultaneously …
From antibacterial to antitumour agents: a brief review on the chemical and medicinal aspects of sulfonamides
H Azevedo-Barbosa, DF Dias, LL Franco… - Mini Reviews in …, 2020 - ingentaconnect.com
Sulfonamides have been in clinical use for many years, and the development of bioactive
substances containing the sulfonamide subunit has grown steadily in view of their important …
substances containing the sulfonamide subunit has grown steadily in view of their important …
Development of novel benzofuran-based SLC-0111 analogs as selective cancer-associated carbonic anhydrase isoform IX inhibitors
In the present study, we describe the design of different series of benzofuran-based
derivatives as potential carbonic anhydrase inhibitors (CAIs). The adopted design is based …
derivatives as potential carbonic anhydrase inhibitors (CAIs). The adopted design is based …
Discovery of 2, 4-thiazolidinedione-tethered coumarins as novel selective inhibitors for carbonic anhydrase IX and XII isoforms
Abstract Different 2, 4-thiazolidinedione-tethered coumarins 5a–b, 10a–n and 11a–d were
synthesised and evaluated for their inhibitory action against the cancer-associated h CAs IX …
synthesised and evaluated for their inhibitory action against the cancer-associated h CAs IX …
Benzofuran-based carboxylic acids as carbonic anhydrase inhibitors and antiproliferative agents against breast cancer
Pursuing our effort for developing effective inhibitors of the cancer-related hCA IX isoform,
here we describe the synthesis of novel benzofuran-based carboxylic acid derivatives …
here we describe the synthesis of novel benzofuran-based carboxylic acid derivatives …
Insights into the effect of elaborating coumarin-based aryl enaminones with sulfonamide or carboxylic acid functionality on carbonic anhydrase inhibitory potency and …
Recently, different mechanisms for inhibition of carbonic anhydrases (CAs) have been
reported, such as the classical zinc-binding (exerted by sulfonamides and carboxylic acids) …
reported, such as the classical zinc-binding (exerted by sulfonamides and carboxylic acids) …
Natural inspired ligustrazine-based SLC-0111 analogues as novel carbonic anhydrase inhibitors
Ligustrazine is the principle bioactive alkaloid in the widely-used Chinese herb Chuan
Xiong rhizome. Herein, a series of novel derivatives has been designed as human carbonic …
Xiong rhizome. Herein, a series of novel derivatives has been designed as human carbonic …