Among patients with asthma, heterogeneity exists regarding the pattern of airway
inflammation and response to treatment, prompting the necessity of recognizing specific …

Fibrosis is a deregulated and ultimately defective form of tissue repair that underlies a large
number of chronic human diseases, as well as obesity and aging. The pathogenesis of …

Increases in the epidermal growth factor receptor (EGFR) have been associated with the
severity of airway thickening in chronic asthmatic subjects, and EGFR signaling is induced …

Background and objective The pathology of asthma is characterized by airway inflammation
(granulocytic (GA) or paucigranulocytic (PGA)) and remodelling of airway structures …

The early growth response gene (Egr-1) codes for a zinc finger transcription factor that has
important roles in the regulation of cell growth, differentiation, and survival. Aberrant Egr-1 …

Early growth response 1 (EGR1), which is involved in cell proliferation, differentiation,
apoptosis, adhesion, migration, and immune and inflammatory responses, is a zinc finger …

Asthma is a heterogeneous disease usually characterized by chronic airway inflammation,
in which several phenotypes have been described, related to the age of onset, symptoms …

The mammalian target of rapamycin (mTOR) signaling pathway integrates environmental
cues, promotes cell growth/differentiation, and regulates immune responses. Although …

During hibernation, small rodents such as hamsters cycle through phases of strongly
suppressed metabolism with low body temperature (torpor) and full restoration of …

Asthma is a chronic inflammatory disease with a high morbidity rate in children and
significantly impacts their healthy growth. It is reported that Th2 cell-mediated airway …