A decade of advances in transposon-insertion sequencing
It has been 10 years since the introduction of modern transposon-insertion sequencing (TIS)
methods, which combine genome-wide transposon mutagenesis with high-throughput …
methods, which combine genome-wide transposon mutagenesis with high-throughput …
Oxygen as a driver of gut dysbiosis
F Rivera-Chávez, CA Lopez, AJ Bäumler - Free Radical Biology and …, 2017 - Elsevier
Abstract Changes in the composition of gut-associated microbial communities may underlie
many inflammatory and allergic diseases. However, the processes that help maintain a …
many inflammatory and allergic diseases. However, the processes that help maintain a …
[HTML][HTML] A gut commensal-produced metabolite mediates colonization resistance to Salmonella infection
A Jacobson, L Lam, M Rajendram, F Tamburini… - Cell host & …, 2018 - cell.com
The intestinal microbiota provides colonization resistance against pathogens, limiting
pathogen expansion and transmission. These microbiota-mediated mechanisms were …
pathogen expansion and transmission. These microbiota-mediated mechanisms were …
Construction and analysis of two genome-scale deletion libraries for Bacillus subtilis
A systems-level understanding of Gram-positive bacteria is important from both an
environmental and health perspective and is most easily obtained when high-quality …
environmental and health perspective and is most easily obtained when high-quality …
High-avidity IgA protects the intestine by enchaining growing bacteria
Vaccine-induced high-avidity IgA can protect against bacterial enteropathogens by directly
neutralizing virulence factors or by poorly defined mechanisms that physically impede …
neutralizing virulence factors or by poorly defined mechanisms that physically impede …
Evolution of bacterial virulence
Bacterial virulence is highly dynamic and context-dependent. For this reason, it is
challenging to predict how molecular changes affect the growth of a pathogen in a host and …
challenging to predict how molecular changes affect the growth of a pathogen in a host and …
[HTML][HTML] Intestinal epithelial NAIP/NLRC4 restricts systemic dissemination of the adapted pathogen Salmonella Typhimurium due to site-specific bacterial PAMP …
Inflammasomes can prevent systemic dissemination of enteropathogenic bacteria. As
adapted pathogens including Salmonella Typhimurium (S. Tm) have evolved evasion …
adapted pathogens including Salmonella Typhimurium (S. Tm) have evolved evasion …
Inflammation boosts bacteriophage transfer between Salmonella spp.
Bacteriophage transfer (lysogenic conversion) promotes bacterial virulence evolution. There
is limited understanding of the factors that determine lysogenic conversion dynamics within …
is limited understanding of the factors that determine lysogenic conversion dynamics within …
Mouse models for bacterial enteropathogen infections: insights into the role of colonization resistance
MKM Herzog, M Cazzaniga, A Peters, N Shayya… - Gut …, 2023 - Taylor & Francis
Globally, enteropathogenic bacteria are a major cause of morbidity and mortality. 1-3
Campylobacter, Salmonella, Shiga-toxin-producing Escherichia coli, and Listeria are among …
Campylobacter, Salmonella, Shiga-toxin-producing Escherichia coli, and Listeria are among …
[HTML][HTML] Epithelium-autonomous NAIP/NLRC4 prevents TNF-driven inflammatory destruction of the gut epithelial barrier in Salmonella-infected mice
The gut epithelium is a critical protective barrier. Its NAIP/NLRC4 inflammasome senses
infection by Gram-negative bacteria, including Salmonella Typhimurium (S. Tm) and …
infection by Gram-negative bacteria, including Salmonella Typhimurium (S. Tm) and …