Chemokines are an indispensable component of our immune system through the regulation
of directional migration and activation of leukocytes. CXCL8 is the most potent human …

Cancer development and its response to therapy are regulated by inflammation, which
either promotes or suppresses tumor progression, potentially displaying opposing effects on …

How glucose metabolism remodels pro-tumor functions of tumor-associated macrophages
(TAMs) needs further investigation. Here we show that M2-like TAMs bear the highest …

The main breakthrough in tumor immunotherapy was the discovery of immune checkpoint
(IC) proteins, which act as a potent suppressor of the immune system by a myriad of …

Recently, immune checkpoint inhibitors (ICIs) therapy has become a promising therapeutic
strategy with encouraging therapeutic outcomes due to their durable anti-tumor effects …

Chemotherapy resistance is a critical contributor to cancer mortality and thus an urgent
unmet challenge in oncology. To characterize chemotherapy resistance processes in high …

The tumor microenvironment (TME) has been identified as one of the driving factors of tumor
progression and invasion. Within this microenvironment, cancer‐associated fibroblasts …

Abstract Background Dysregulation of circular RNAs (circRNAs) plays an important role in
the development of gastric cancer; thus, revealing the biological and molecular mechanisms …

Single agent checkpoint inhibitor therapy has not been effective for most gastrointestinal
solid tumors, but combination therapy with drugs targeting additional immunosuppressive …

Macrophages, a type of myeloid immune cell, play essential roles in fighting against
pathogenic invasion and activating T cell-mediated adaptive immune responses. As a major …