Iron deficiency anemia (IDA) is a major problem in chronic kidney disease (CKD), causing
increased mortality. Ferritin stores iron, representing iron status. Hepcidin binds to …

It is generally believed that diseases caused by oxidative stress should be treated with
antioxidants. However, clinical trials with such antioxidants as ascorbic acid and vitamin E …

Abstract" Serum ferritin" presents a paradox, as the iron storage protein ferritin is not
synthesised in serum yet is to be found there. Serum ferritin is also a well known …

Before the introduction of erythropoiesis-stimulating agents (ESAs) in 1989, repeated
transfusions given to patients with end-stage renal disease caused iron overload, and the …

Renal anemia is a complication of chronic kidney disease. Guidelines for safe and effective
treatment in patients with renal anemia are needed. The Japanese Society for Dialysis …

Crohn's disease and ulcerative colitis, known together as inflammatory bowel diseases
(IBDs), and celiac disease are the most common disorders affecting not only adults but also …

Excess free iron generates oxidative stress that hallmarks diseases of aging. The
observation that patients with Alzheimer's disease or Parkinson's disease show a dramatic …

BACKGROUND: Most dialysis patients receiving erythropoesis-stimulating agents (ESA)
also receive parenteral iron supplementation. There are few data on the risk of …

The production of erythropoietin (EPO), the main regulator of erythroid differentiation, is
regulated by hypoxia-inducible factor (HIF). HIF2α seems to be the principal regulator of …

Iron is an essential element for human life. However, it is a pro-oxidant agent capable of
reacting with hydrogen peroxide. An iron overload can cause cellular changes, such as …