The rapid growth of obesity worldwide has made it a major health problem, while the
dramatic increase in the prevalence of obesity has had a significant impact on the …

The 12/15-lipoxygenase enzymes react with fatty acids producing active lipid metabolites
that are involved in a number of significant disease states. The latter include type 1 and type …

Excess adiposity can induce adverse sequelae in multiple cell types and organ systems.
The transition from the lean to the obese state is characterized by fundamental cellular …

944 Hypertension May 2013 bioavailable nitric oxide. 15–19 The decreased bioavailability
of nitric oxide reduces endothelial-mediated vascular relaxation and promotes vascular …

Alterations in the renin angiotensin aldosterone system (RAAS) contribute to the underlying
pathophysiology of insulin resistance in humans; however, individual differences in the …

Obesity is a worldwide disease that is accompanied by several metabolic abnormalities
such as hypertension, hyperglycemia and dyslipidemia. The accelerated adipose tissue …

Background Clinical studies show that metformin attenuates all‐cause mortality and
myocardial infarction compared with other medications for type 2 diabetes, even at similar …

Obesity is an independent risk factor for the development and progression of chronic kidney
disease and one of the emerging reasons for end-stage renal disease owing to its dramatic …

Autoimmunity is a well-known pathogenic component in type 1 diabetes (T1DM). The
assumption that the pathogenesis of type 2 diabetes (T2DM) also encompasses …

Adipose tissue inflammation and reduced pancreatic β-cell function are key issues in the
development of cardiovascular disease and progressive metabolic dysfunction in type 2 …