malnutrition/sarcopenia and frailty in patients with cirrhosis

C Bunchorntavakul, KR Reddy - Alimentary pharmacology & …, 2020 - Wiley Online Library
Background Malnutrition/sarcopenia and frailty are common in patients with cirrhosis and
are associated with poor outcomes. Aim To provide an overview of data on the importance …

Assessment of malnutrition, sarcopenia and frailty in patients with cirrhosis: which tools should we use in clinical practice?

B Buchard, Y Boirie, L Cassagnes, G Lamblin, A Coilly… - Nutrients, 2020 - mdpi.com
Malnutrition is a common comorbidity in patients with cirrhosis. Its prognostic value is
indisputable as it greatly affects the evolution of liver diseases. It has a major impact on both …

Malnutrition, frailty, and sarcopenia in patients with cirrhosis: 2021 practice guidance by the American Association for the Study of Liver Diseases

JC Lai, P Tandon, W Bernal, EB Tapper, U Ekong… - …, 2021 - Wiley Online Library
This is the first American Association for the Study of Liver Diseases (AASLD) practice
guidance on the management of malnutrition, frailty, and sarcopenia in patients with …

Effect of diabetes medications and glycemic control on risk of hepatocellular cancer in patients with nonalcoholic fatty liver disease

JR Kramer, Y Natarajan, J Dai, X Yu, L Li… - …, 2022 - Wiley Online Library
Abstract Background and Aims In patients with NAFLD, those with type 2 diabetes mellitus
(DM) have a high risk of progression to HCC. However, the determinants of HCC risk in …

[PDF][PDF] Immune‐Responsive Gene 1/Itaconate Activates Nuclear Factor Erythroid 2–Related Factor 2 in Hepatocytes to Protect Against Liver Ischemia–Reperfusion …

Z Yi, M Deng, MJ Scott, G Fu, PA Loughran, Z Lei… - …, 2020 - Wiley Online Library
Background and Aims Itaconate, a metabolite of the tricarboxylic acid cycle, plays anti‐
inflammatory roles in macrophages during endotoxemia. The mechanisms underlying its …

Pediatric sarcopenia: a paradigm in the overall definition of malnutrition in children?

PH Ooi, S Thompson‐Hodgetts… - Journal of Parenteral …, 2020 - Wiley Online Library
Background Malnutrition is a common complication in children with chronic diseases.
Sarcopenia is one component of malnutrition, characterized by reduced skeletal muscle …

Frailty is associated with increased risk of cirrhosis disease progression and death

S Wang, R Whitlock, C Xu, S Taneja, S Singh… - …, 2022 - Wiley Online Library
Abstract Background and Aims The Liver Frailty Index (LFI) is a well‐studied tool that
evaluates frailty in patients with cirrhosis. Consisting of grip strength, chair stands, and …

Frailty, mortality, and health care utilization after liver transplantation: From the Multicenter Functional Assessment in Liver Transplantation (FrAILT) Study

JC Lai, AM Shui, A Duarte‐Rojo, DR Ganger… - Hepatology, 2022 - journals.lww.com
Conclusions Compared with nonfrail patients, frail LT recipients had a higher risk of post‐LT
death and greater post‐LT health care utilization, although overall post‐LT survival was …

Fatty liver disease: diagnosis and stratification

Y Saiman, A Duarte-Rojo… - Annual review of …, 2022 - annualreviews.org
Nonalcoholic fatty liver disease (NAFLD) is a major public health crisis affecting
approximately 25% of the world's population. The spectrum of NAFLD ranges from bland …

Identifying an optimal liver frailty index cutoff to predict waitlist mortality in liver transplant candidates

A Kardashian, J Ge, CE McCulloch, MR Kappus… - Hepatology, 2021 - journals.lww.com
Conclusions Unchaperoned iron in PCBP1‐deleted mouse hepatocytes leads to production
of ROS, resulting in lipid peroxidation (LPO) and steatosis in the absence of iron overload …