Doxorubicin exerts cytotoxic effects through cell cycle arrest and Fas-mediated cell death
HS Kim, YS Lee, DK Kim - Pharmacology, 2009 - karger.com
Doxorubicin (DOX) is involved in the induction of DNA damage, inhibition of cell
proliferation, impairment of mitochondria, and cell death. To determine the biological effects …
proliferation, impairment of mitochondria, and cell death. To determine the biological effects …
Anthracyclines and mitochondria
A Mordente, E Meucci, A Silvestrini… - Advances in …, 2012 - Springer
Anthracyclines remain the cornerstone in the treatment of many malignancies including
lymphomas, leukaemias, and sarcomas. Unfortunately, the clinical use of these potent …
lymphomas, leukaemias, and sarcomas. Unfortunately, the clinical use of these potent …
Dendrimer conjugation enhances tumor penetration and efficacy of doxorubicin in extracellular matrix-expressing 3D lung cancer models
Doxorubicin (DOX) is a chemotherapeutic agent broadly used in the treatment of a range of
solid tumors. In spite of its high potency, as is the case for many other chemotherapeutic …
solid tumors. In spite of its high potency, as is the case for many other chemotherapeutic …
Didymin, a dietary flavonoid glycoside from citrus fruits, induces Fas-mediated apoptotic pathway in human non-small-cell lung cancer cells in vitro and in vivo
JY Hung, YL Hsu, YC Ko, YM Tsai, CJ Yang… - Lung cancer, 2010 - Elsevier
Epidemiological studies provided evidence that the high dietary intake of flavonoids with
fruits and vegetables could be associated with lower cancer prevalence in humans …
fruits and vegetables could be associated with lower cancer prevalence in humans …
Cordycepin sensitizes cholangiocarcinoma cells to be killed by natural killer-92 (NK-92) cells
S Panwong, M Wathikthinnakon, T Kaewkod… - Molecules, 2021 - mdpi.com
Immunotherapy harnessing immune functions is a promising strategy for cancer treatment.
Tumor sensitization is one approach to enhance tumor cell susceptibility to immune cell …
Tumor sensitization is one approach to enhance tumor cell susceptibility to immune cell …
Doxorubicin-conjugated polypeptide nanoparticles inhibit metastasis in two murine models of carcinoma
Drug delivery vehicles are often assessed for their ability to control primary tumor growth, but
the outcome of cancer treatment depends on controlling or inhibiting metastasis. Therefore …
the outcome of cancer treatment depends on controlling or inhibiting metastasis. Therefore …
Glycosylated copper (II) ionophores as prodrugs for β-glucosidase activation in targeted cancer therapy
8-Hydroxyquinoline derivatives are metal-binding compounds that have recently attracted
interest as therapeutic agents for cancer therapy. In this scenario, we designed and …
interest as therapeutic agents for cancer therapy. In this scenario, we designed and …
[HTML][HTML] Recent developments in the identification and biosynthesis of antitumor drugs derived from microorganisms
Q Gao, S Deng, T Jiang - Engineering Microbiology, 2022 - Elsevier
Secondary metabolites in microorganisms represent a resource for drug discovery and
development. In particular, microbial-derived antitumor agents are in clinical use worldwide …
development. In particular, microbial-derived antitumor agents are in clinical use worldwide …
Sulfuretin from heartwood of Rhus verniciflua triggers apoptosis through activation of Fas, Caspase‐8, and the mitochondrial death pathway in HL‐60 human …
Sulfuretin, a flavonoid isolated from heartwood of Rhus verniciflua, has been reported to
have anti‐cancer activities but the underlying molecular mechanism was not clear. In this …
have anti‐cancer activities but the underlying molecular mechanism was not clear. In this …