Gene expression–based prognostic signatures in lung cancer: ready for clinical use?

J Subramanian, R Simon - Journal of the National Cancer …, 2010 - academic.oup.com
A substantial number of studies have reported the development of gene expression–based
prognostic signatures for lung cancer. The ultimate aim of such studies should be the …

Prognostic immune markers in non–small cell lung cancer

K Suzuki, SS Kachala, K Kadota, R Shen, Q Mo… - Clinical Cancer …, 2011 - AACR
Tumor-associated immune responses have polarized effects in regulating tumor growth.
Although a clear association has been shown between the tumor immune response and …

ibex: An open infrastructure software platform to facilitate collaborative work in radiomics

L Zhang, DV Fried, XJ Fave, LA Hunter, J Yang… - Medical …, 2015 - Wiley Online Library
Purpose: Radiomics, which is the high‐throughput extraction and analysis of quantitative
image features, has been shown to have considerable potential to quantify the tumor …

A practical molecular assay to predict survival in resected non-squamous, non-small-cell lung cancer: development and international validation studies

JR Kratz, J He, SK Van Den Eeden, ZH Zhu, W Gao… - The Lancet, 2012 - thelancet.com
Background The frequent recurrence of early-stage non-small-cell lung cancer (NSCLC) is
generally attributable to metastatic disease undetected at complete resection. Management …

[HTML][HTML] The International Association for the Study of Lung Cancer Staging Project: prognostic factors and pathologic TNM stage in surgically managed non-small cell …

K Chansky, JP Sculier, JJ Crowley, D Giroux… - Journal of thoracic …, 2009 - Elsevier
Purpose: To assess the impact of cell type, age, and gender in addition to pathologic tumor,
node, metastasis (TNM) stage in surgically managed stage I-IIIA non-small cell lung cancer …

Prognostic value and reproducibility of pretreatment CT texture features in stage III non-small cell lung cancer

DV Fried, SL Tucker, S Zhou, Z Liao, O Mawlawi… - International Journal of …, 2014 - Elsevier
Purpose To determine whether pretreatment CT texture features can improve patient risk
stratification beyond conventional prognostic factors (CPFs) in stage III non-small cell lung …

Folic acid-modified dendrimer-entrapped gold nanoparticles as nanoprobes for targeted CT imaging of human lung adencarcinoma

H Wang, L Zheng, C Peng, M Shen, X Shi, G Zhang - Biomaterials, 2013 - Elsevier
We report a new usage of folic acid-modified dendrimer-entrapped gold nanoparticles (Au
DENPs-FA) as nanoprobes for in vitro and in vivo targeted computed tomography (CT) …

A clonal expression biomarker associates with lung cancer mortality

D Biswas, NJ Birkbak, R Rosenthal, CT Hiley, EL Lim… - Nature medicine, 2019 - nature.com
An aim of molecular biomarkers is to stratify patients with cancer into disease subtypes
predictive of outcome, improving diagnostic precision beyond clinical descriptors such as …

Wnt3a: functions and implications in cancer

S He, Y Lu, X Liu, X Huang, ET Keller, CN Qian… - Chinese journal of …, 2015 - Springer
Wnt3a, one of Wnt family members, plays key roles in regulating pleiotropic cellular
functions, including self-renewal, proliferation, differentiation, and motility. Accumulating …

Prognostic and predictive value of a malignancy-risk gene signature in early-stage non–small cell lung cancer

DT Chen, YL Hsu, WJ Fulp, D Coppola… - Journal of the …, 2011 - academic.oup.com
Background The malignancy-risk gene signature is composed of numerous proliferative
genes and has been applied to predict breast cancer risk. We hypothesized that the …