Aminoacyl-tRNA synthetases (ARSs) are essential enzymes for protein synthesis with
evolutionarily conserved enzymatic mechanisms. Despite their similarity across organisms …

Nontranslational functions of vertebrate aminoacyl tRNA synthetases (aaRSs), which
catalyze the production of aminoacyl-tRNAs for protein synthesis, have recently been …

Amino acids are required for activation of the mammalian target of rapamycin (mTOR)
kinase, which regulates protein translation, cell size, and autophagy. However, the amino …

Over the course of evolution, eukaryotic aminoacyl-tRNA synthetases (aaRSs) progressively
incorporated domains and motifs that have no essential connection to aminoacylation …

Although key tumorigenic and tumor-suppressive factors have been unveiled over the last
several decades, cancer remains the most life-threatening disease. Multiomic analyses of …

The aminoacyl‐tRNA synthetases are prominently known for their classic function in the first
step of protein synthesis, where they bear the responsibility of setting the genetic code. Each …

Aminoacyl-tRNA synthetases (ARSs) are a family of evolutionarily conserved housekeeping
enzymes used for protein synthesis that have pivotal roles in the ligation of tRNA with their …

Known as an essential component of the translational apparatus, the aminoacyl-tRNA
synthetase family catalyzes the first step reaction in protein synthesis, that is, to specifically …

Although adaptive systems of immunity against tumor initiation and destruction are well
investigated, less understood is the role, if any, of endogenous factors that have …

The formation of a functional blood vessel network relies on the ability of endothelial cells
(ECs) to dynamically rearrange their adhesive contacts in response to blood flow and …