The tumor microenvironment can be hypoxic, acidic, and deficient in nutrients, thus causing
the metabolism of tumor cells as well as the neighboring stromal cells to be remodelled to …

Acylcarnitines play an essential role in regulating the balance of intracellular sugar and lipid
metabolism. They serve as carriers to transport activated long-chain fatty acids into …

Background Lung cancer (LC) is one of the most aggressive, prevalent and fatal
malignancies. Gut microbes and their associated metabolites are thought to cause and …

Nuclear factor-E2-related factor 2 (Nrf2) is a key transcription factor known to be involved in
maintaining cell redox balance and signal transduction and plays central role in reducing …

New insights into tumor-associated metabolic reprogramming have provided novel
vulnerabilities that can be targeted for cancer therapy. Here, we propose a mass …

Glioblastoma multiforme (GBM) undergoes metabolic reprogramming to meet the high ATP
and anabolic demands of the tumor cells. However, the role of fatty acid oxidation (FAO) and …

The importance of fatty acid (FA) metabolism in cancer is well-established, yet the
mechanisms underlying metabolic reprogramming remain elusive. Here, we identify …

Cancer cells must maintain metabolic homeostasis under a wide range of conditions and
meet their own energy needs in order to survive and reproduce. In addition to glycolysis …

Aberrant lipid metabolism is nonnegligible for tumor cells to adapt to the tumor
microenvironment (TME). It plays a significant role in the amount and function of immune …

Senescence is an inevitable biological process. Disturbances in glucose and lipid
metabolism are essential features of cellular senescence. Given the important roles of these …