Systematic review: impact of resveratrol exposure during pregnancy on maternal and fetal outcomes in animal models of human pregnancy complications—are we …

JRT Darby, MHBM Dollah, TRH Regnault… - Pharmacological …, 2019 - Elsevier
Resveratrol (RSV) has been reported to have potential beneficial effects in the complicated
pregnancy. Various pregnancy complications lead to a suboptimal in utero environment that …

Reduced neurosteroid exposure following preterm birth and its' contribution to neurological impairment: a novel avenue for preventative therapies

JC Shaw, MJ Berry, RM Dyson, GK Crombie… - Frontiers in …, 2019 - frontiersin.org
Children born preterm are at an increased risk of developing cognitive problems and neuro-
behavioral disorders such as attention deficit hyperactivity disorder (ADHD) and anxiety …

Effects of prenatal stress on behavioural and neurodevelopmental outcomes are altered by maternal separation in the neonatal period

GK Crombie, HK Palliser, JC Shaw… - …, 2021 - Elsevier
Background Chronic psychosocial stress during pregnancy and/or after birth, and the
associated elevation in cortisol, is linked with the onset of behavioural disorders in …

Prenatal hypoxia impairs cardiac mitochondrial and ventricular function in guinea pig offspring in a sex-related manner

LP Thompson, L Chen, BM Polster… - American Journal of …, 2018 - journals.physiology.org
Adverse intrauterine conditions cause fetal growth restriction and increase the risk of adult
cardiovascular disease. We hypothesize that intrauterine hypoxia impairs fetal heart …

Prenatal stress induces translational disruption associated with myelination deficits

GK Crombie, HK Palliser, JC Shaw, BA Hanley… - Dev. Neurosci, 2023 - karger.com
Disruptions to neurodevelopment are known to be linked to behavioral disorders in
childhood and into adulthood. The fetal brain is extremely vulnerable to stimuli that alter …

Neurosteroid replacement therapy using the allopregnanolone-analogue ganaxolone following preterm birth in male guinea pigs

JC Shaw, RM Dyson, HK Palliser, C Gray, MJ Berry… - Pediatric …, 2019 - nature.com
Background Children born preterm, especially boys, are at increased risk of developing
attention deficit hyperactivity disorder (ADHD) and learning difficulties. We propose that …

Evaluating changes in GABAergic and glutamatergic pathways in early life following prenatal stress and postnatal neurosteroid supplementation

GK Crombie, HK Palliser, JC Shaw… - …, 2022 - Elsevier
Background A correct balance of activity of the GABA and glutamate systems is vital for
optimal neurodevelopment and general CNS function, and the dysregulation of this balance …

Hepatic cytochrome P450 function is reduced by life-long Western diet consumption in guinea pig independent of birth weight

MD Wiese, AS Meakin, TJ Varcoe, JRT Darby, O Sarr… - Life Sciences, 2021 - Elsevier
Introduction Non-alcoholic fatty liver disease (NAFLD) is characterised by accumulation of
triglycerides and cholesterol within the liver and dysregulation of specific hepatic …

Adult vascular dysfunction in foetal growth‐restricted guinea‐pigs is associated with a neonate‐adult switching in Nos3 DNA methylation

BJ Krause, E Peñaloza, A Candia, D Cañas… - Acta …, 2019 - Wiley Online Library
Aim Foetal growth restriction (FGR) is associated with endothelial dysfunction and
cardiovascular diseases in adult subjects. Early vascular remodelling and epigenetic …

[PDF][PDF] This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and …

DRP D FRASER, MR Heider, R Swennen… - researchgate.net
Roots, tubers and bananas (RTB) are vital staples for food security in the worlds' poorest
nations. A major constraint to current RTB breeding programmes is limited knowledge about …