Non-canonical WNT signalling in cardiovascular disease: mechanisms and therapeutic implications

I Akoumianakis, M Polkinghorne… - Nature Reviews …, 2022 - nature.com
WNT signalling comprises a diverse spectrum of receptor-mediated pathways activated by a
large family of WNT ligands and influencing fundamental biological processes. WNT …

[HTML][HTML] Pathophysiology of obesity and its associated diseases

X Jin, T Qiu, L Li, R Yu, X Chen, C Li, CG Proud… - … Pharmaceutica Sinica B, 2023 - Elsevier
The occurrence of obesity has increased across the whole world. Many epidemiological
studies have indicated that obesity strongly contributes to the development of cancer …

Mechanistic insights of empagliflozin in nondiabetic patients with HFrEF: from the EMPA-TROPISM study

JA Requena-Ibáñez, CG Santos-Gallego… - Heart Failure, 2021 - jacc.org
Objectives The goal of this study was to evaluate the effect of empagliflozin, in addition to
optimal medical treatment, on epicardial adipose tissue (EAT), interstitial myocardial fibrosis …

Obesity, estrogens and adipose tissue dysfunction–implications for pulmonary arterial hypertension

KM Mair, R Gaw, MR MacLean - Pulmonary circulation, 2020 - journals.sagepub.com
Obesity is a prevalent global public health issue characterized by excess body fat. Adipose
tissue is now recognized as an important endocrine organ releasing an abundance of …

Adipokines and inflammation: focus on cardiovascular diseases

S Feijóo-Bandín, A Aragón-Herrera… - International journal of …, 2020 - mdpi.com
It is well established that adipose tissue, apart from its energy storage function, acts as an
endocrine organ that produces and secretes a number of bioactive substances, including …

Adipose tissue development and expansion from the womb to adolescence: an overview

CE Orsso, E Colin-Ramirez, CJ Field, KL Madsen… - Nutrients, 2020 - mdpi.com
Prevalence rates of pediatric obesity continue to rise worldwide. Adipose tissue (AT)
development and expansion initiate in the fetus and extend throughout the lifespan. This …

Excessive accumulation of epicardial adipose tissue promotes microvascular obstruction formation after myocardial ischemia/reperfusion through modulating …

J Zhao, W Cheng, Y Dai, Y Li, Y Feng, Y Tan… - Cardiovascular …, 2024 - Springer
Background Owing to its unique location and multifaceted metabolic functions, epicardial
adipose tissue (EAT) is gradually emerging as a new metabolic target for coronary artery …

The evolving view of thermogenic fat and its implications in cancer and metabolic diseases

X Yin, Y Chen, R Ruze, R Xu, J Song… - Signal Transduction and …, 2022 - nature.com
The incidence of metabolism-related diseases like obesity and type 2 diabetes mellitus has
reached pandemic levels worldwide and increased gradually. Most of them are listed on the …

Secretory products from epicardial adipose tissue induce adverse myocardial remodeling after myocardial infarction by promoting reactive oxygen species …

S Hao, X Sui, J Wang, J Zhang, Y Pei, L Guo… - Cell Death & …, 2021 - nature.com
Adverse myocardial remodeling, manifesting pathologically as myocardial hypertrophy and
fibrosis, often follows myocardial infarction (MI) and results in cardiac dysfunction. In this …

Metabolic syndrome, fatty liver, and artificial intelligence-based epicardial adipose tissue measures predict long-term risk of cardiac events: a prospective study

A Lin, ND Wong, A Razipour, PA McElhinney… - Cardiovascular …, 2021 - Springer
Background We sought to evaluate the association of metabolic syndrome (MetS) and
computed tomography (CT)-derived cardiometabolic biomarkers (non-alcoholic fatty liver …