Non-canonical WNT signalling in cardiovascular disease: mechanisms and therapeutic implications
I Akoumianakis, M Polkinghorne… - Nature Reviews …, 2022 - nature.com
WNT signalling comprises a diverse spectrum of receptor-mediated pathways activated by a
large family of WNT ligands and influencing fundamental biological processes. WNT …
large family of WNT ligands and influencing fundamental biological processes. WNT …
[HTML][HTML] Pathophysiology of obesity and its associated diseases
The occurrence of obesity has increased across the whole world. Many epidemiological
studies have indicated that obesity strongly contributes to the development of cancer …
studies have indicated that obesity strongly contributes to the development of cancer …
Mechanistic insights of empagliflozin in nondiabetic patients with HFrEF: from the EMPA-TROPISM study
JA Requena-Ibáñez, CG Santos-Gallego… - Heart Failure, 2021 - jacc.org
Objectives The goal of this study was to evaluate the effect of empagliflozin, in addition to
optimal medical treatment, on epicardial adipose tissue (EAT), interstitial myocardial fibrosis …
optimal medical treatment, on epicardial adipose tissue (EAT), interstitial myocardial fibrosis …
Obesity, estrogens and adipose tissue dysfunction–implications for pulmonary arterial hypertension
KM Mair, R Gaw, MR MacLean - Pulmonary circulation, 2020 - journals.sagepub.com
Obesity is a prevalent global public health issue characterized by excess body fat. Adipose
tissue is now recognized as an important endocrine organ releasing an abundance of …
tissue is now recognized as an important endocrine organ releasing an abundance of …
Adipokines and inflammation: focus on cardiovascular diseases
S Feijóo-Bandín, A Aragón-Herrera… - International journal of …, 2020 - mdpi.com
It is well established that adipose tissue, apart from its energy storage function, acts as an
endocrine organ that produces and secretes a number of bioactive substances, including …
endocrine organ that produces and secretes a number of bioactive substances, including …
Adipose tissue development and expansion from the womb to adolescence: an overview
Prevalence rates of pediatric obesity continue to rise worldwide. Adipose tissue (AT)
development and expansion initiate in the fetus and extend throughout the lifespan. This …
development and expansion initiate in the fetus and extend throughout the lifespan. This …
Excessive accumulation of epicardial adipose tissue promotes microvascular obstruction formation after myocardial ischemia/reperfusion through modulating …
J Zhao, W Cheng, Y Dai, Y Li, Y Feng, Y Tan… - Cardiovascular …, 2024 - Springer
Background Owing to its unique location and multifaceted metabolic functions, epicardial
adipose tissue (EAT) is gradually emerging as a new metabolic target for coronary artery …
adipose tissue (EAT) is gradually emerging as a new metabolic target for coronary artery …
The evolving view of thermogenic fat and its implications in cancer and metabolic diseases
X Yin, Y Chen, R Ruze, R Xu, J Song… - Signal Transduction and …, 2022 - nature.com
The incidence of metabolism-related diseases like obesity and type 2 diabetes mellitus has
reached pandemic levels worldwide and increased gradually. Most of them are listed on the …
reached pandemic levels worldwide and increased gradually. Most of them are listed on the …
Secretory products from epicardial adipose tissue induce adverse myocardial remodeling after myocardial infarction by promoting reactive oxygen species …
S Hao, X Sui, J Wang, J Zhang, Y Pei, L Guo… - Cell Death & …, 2021 - nature.com
Adverse myocardial remodeling, manifesting pathologically as myocardial hypertrophy and
fibrosis, often follows myocardial infarction (MI) and results in cardiac dysfunction. In this …
fibrosis, often follows myocardial infarction (MI) and results in cardiac dysfunction. In this …
Metabolic syndrome, fatty liver, and artificial intelligence-based epicardial adipose tissue measures predict long-term risk of cardiac events: a prospective study
Background We sought to evaluate the association of metabolic syndrome (MetS) and
computed tomography (CT)-derived cardiometabolic biomarkers (non-alcoholic fatty liver …
computed tomography (CT)-derived cardiometabolic biomarkers (non-alcoholic fatty liver …