Oxidative cyclizations are important transformations that occur widely during natural product
biosynthesis. The transformations from acyclic precursors to cyclized products can afford …

Covering: 2010 to 2022 Heterologous expression of natural product biosynthetic gene
clusters (BGCs) has become a widely used tool for genome mining of cryptic pathways …

We have studied the cation–π interactions of neutral aromatic ligands with the cationic
amino acid residues arginine, histidine and lysine using ab initio calculations, symmetry …

The construction of O-heterocycles is an important step in organic synthesis and
biosynthesis for producing valuable ring compounds. Although enzyme-catalysed five-or six …

Type I modular polyketide synthases are homodimeric multidomain assembly line enzymes
that synthesize a variety of polyketide natural products by performing polyketide chain …

The Baldwin rules constitute one of the clearest examples of the success which can be
obtained through the application of stereoelectronic concepts to reaction design. With …

Monensin A is a prototypical natural polyether polyketide antibiotic. It acts by binding a metal
cation and facilitating its transport across the cell membrane. Biosynthesis of monensin A …

The importance of intramolecular constraints in cyclic transition-state geometries is
especially pronounced in n-endo-tet cyclizations, where the usual backside approach of a …

Truly important scientific breakthroughs often come from catching the glimpses of order in
chaos and distilling a large body of disjointed data into a clear set of simple concepts. Even …

Biocatalysis is based on the application of natural catalysts for new purposes, for which
enzymes were not designed. Although the first examples of biocatalysis were reported more …