Biological systems are composed of heterogeneous populations of cells that
intercommunicate to form a functional living tissue. Biological function varies greatly across …

Compositional diversity is a fundamental property in cell populations. Single‐cell analysis
promises new insight into this cellular heterogeneity on the genomic, transcriptomic …

Molecular analysis on the single-cell level represents a rapidly growing field in the life
sciences. While bulk analysis from a pool of cells provides a general molecular profile, it is …

The chemical differences between individual cells within large cellular populations provide
unique information on organisms' homeostasis and the development of diseased states …

Advances of analytical methods and emerging microfluidic tools have made it possible to
investigate biological processes in living organisms in detail and reach sensitivities sufficient …

An important number of healthy and diseased tissues shows spatial variations in their
metabolic capacities across the tissue. The liver is a prime example of such heterogeneity …

Single-cell metabolite analysis provides valuable information on cellular function and
response to external stimuli. While recent advances in mass spectrometry reached the …

Heterogeneity in cell populations is a phenomenon encountered in virtually all biological
systems, in whole tissues and cell cultures and from bacterial to mammalian cells. Moreover …

The pancreatic beta cell functions as a key regulator of blood glucose levels by integrating a
variety of signals in response to changing metabolic demands. Variations in beta cell identity …

Molecular profiling of single cells has the potential to significantly advance our
understanding of cell function and cellular processes of importance to health and disease. In …