The roles of FLOT1 in human diseases

Z Zhan, M Ye, X Jin - Molecular Medicine Reports, 2023 - spandidos-publications.com
FLOT1, a scaffold protein of lipid rafts, is involved in several biological processes, including
lipid raft protein‑dependent or clathrin‑independent endocytosis, and the formation of …

[HTML][HTML] Role of metabolic reprogramming of long non-coding RNA in clear cell renal cell carcinoma

H Zhang, L Yu, J Chen, L Liu, X Yang, H Cui… - Journal of …, 2022 - ncbi.nlm.nih.gov
Renal cell carcinoma (RCC), one of the most frequent cancers, is a" classical" malignancy
characterized by metabolic reprogramming. Clear cell renal cell carcinoma (ccRCC) is its …

Pre-organized landscape of T cell surface

Y Jung - Frontiers in Immunology, 2023 - frontiersin.org
T cell activation is initiated by the recognition of specific antigenic peptides and
subsequently accomplished by complex signaling cascades. These aspects have been …

Microbial uptake in oral mucosa–draining lymph nodes leads to rapid release of cytotoxic CD8+ T cells lacking a gut-homing phenotype

J Barreto de Albuquerque, LM Altenburger, J Abe… - Science …, 2022 - science.org
The gastrointestinal (GI) tract constitutes an essential barrier against ingested microbes,
including potential pathogens. Although immune reactions are well studied in the lower GI …

Flotillin‐1 is a prognostic biomarker for glioblastoma and promotes cancer development through enhancing invasion and altering tumour microenvironment

R Wang, Z Chen, Y Zhang, S Xiao… - Journal of Cellular …, 2023 - Wiley Online Library
Abstract Flotillin‐1 (FLOT1) has long been recognized as a tumour‐promoting gene in
several types of cancer. However, the expression and function of FLOT1 in glioblastomas …

Molecular characterization and function of the lipid raft protein Lvflotillin-1A from Litopenaeus vannamei

S Li, H Shi, L Ruan, L Liu, C Wang - Fish & Shellfish Immunology, 2022 - Elsevier
White spot syndrome virus (WSSV) can cause a contagious, high virulent and pandemic
disease for crustaceans, especially shrimps. However, the molecular mechanism of WSSV …

MicroRNA‑485‑5p suppresses the progression of esophageal squamous cell carcinoma by targeting flotillin‑1 and inhibits the epithelial‑mesenchymal transition

R Zhao, Y Shan, X Zhou, C Zhang… - Oncology …, 2021 - spandidos-publications.com
As esophageal squamous cell carcinoma (ESCC) is one of the most frequently diagnosed
cancers in Asia, it is crucial to uncover its underlying molecular mechanisms that support its …

Synthetic lipid rafts formed by cholesterol nano-patch induce T cell activation

Y Jung, YJ Kim, S Lee, J Nam, S Ha, J Cheon, M Kwak - bioRxiv, 2023 - biorxiv.org
Lipid rafts are small and dynamic membrane compartments that are enriched with
cholesterols or sphingolipids. The coalescence of small lipid rafts into a large lipid raft forms …

Immunogenetics of lupus erythematosus

B Ünlü, Ü Türsen, N Jabalameli… - The Immunogenetics of …, 2022 - Springer
Lupus erythematosus (LE) is a heterogeneous disease with a wide range of manifestations
ranging from localized lesions in cutaneous lupus erythematosus (CLE) to severe …

Caveolin-1, tetraspanin CD81 and flotillins in lymphocyte cell membrane organization, signaling and immunopathology

AM Schaffer, S Minguet - Biochemical Society Transactions, 2020 - portlandpress.com
The adaptive immune system relies on B and T lymphocytes to ensure a specific and long-
lasting protection of an individual from a wide range of potential pathogenic hits …