The 3D organization of mammalian chromatin was described more than 30 years ago by
visualizing sites of DNA synthesis at different times during the S phase of the cell cycle …

Rapidly developing technologies have recently fueled an exciting era of discovery in the
field of chromosome structure and nuclear organization. In addition to chromosome …

Immediately following the discovery of the structure of DNA and the semi-conservative
replication of the parental DNA sequence into two new DNA strands, it became apparent …

In eukaryotic cells, genome duplication is temporally organised according to a program
referred to as the replication-timing (RT) program. The RT of individual genomic domains …

Decades of work on the spatiotemporal organization of mammalian DNA replication timing
(RT) continues to unveil novel correlations with aspects of transcription and chromatin …

Three-dimensional genome organisation and replication timing are known to be correlated,
however, it remains unknown whether nuclear architecture overall plays an instructive role …

Computational biology is enabling an explosive growth in our understanding of stem cells
and our ability to use them for disease modeling, regenerative medicine, and drug …

We developed a nonequilibrium model to study chromosome structural reorganizations
within a simplified cell developmental system. From the chromosome structural perspective …

Background Chromatin contacts are essential for gene-expression regulation; however,
obtaining a high-resolution genome-wide chromatin contact map is still prohibitively …

The spatial segregation of the genome into compartments is a major feature of 3D genome
organization. New data on mammalian chromosome organization across different conditions …