EGF receptor trafficking: consequences for signaling and cancer
A Tomas, CE Futter, ER Eden - Trends in cell biology, 2014 - cell.com
The ligand-stimulated epidermal growth factor receptor (EGFR) has been extensively
studied in the analysis of molecular mechanisms regulating endocytic traffic and the role of …
studied in the analysis of molecular mechanisms regulating endocytic traffic and the role of …
Protein localization in disease and therapy
The eukaryotic cell is organized into membrane-covered compartments that are
characterized by specific sets of proteins and biochemically distinct cellular processes. The …
characterized by specific sets of proteins and biochemically distinct cellular processes. The …
Endocytosis and signaling: cell logistics shape the eukaryotic cell plan
S Sigismund, S Confalonieri, A Ciliberto… - Physiological …, 2012 - journals.physiology.org
Our understanding of endocytosis has evolved remarkably in little more than a decade. This
is the result not only of advances in our knowledge of its molecular and biological workings …
is the result not only of advances in our knowledge of its molecular and biological workings …
Nuclear EGFR as a molecular target in cancer
TM Brand, M Iida, N Luthar, MM Starr… - Radiotherapy and …, 2013 - Elsevier
The epidermal growth factor receptor (EGFR) has been one of the most targeted receptors in
the field of oncology. While anti-EGFR inhibitors have demonstrated clinical success in …
the field of oncology. While anti-EGFR inhibitors have demonstrated clinical success in …
[HTML][HTML] The nuclear epidermal growth factor receptor signaling network and its role in cancer
TM Brand, M Iida, C Li, DL Wheeler - Discovery medicine, 2011 - ncbi.nlm.nih.gov
The epidermal growth factor receptor (EGFR) is a member of the EGFR family of receptor
tyrosine kinases (RTKs). EGFR activation via ligand binding results in signaling through …
tyrosine kinases (RTKs). EGFR activation via ligand binding results in signaling through …
Landscape of EGFR signaling network in human cancers: biology and therapeutic response in relation to receptor subcellular locations
W Han, HW Lo - Cancer letters, 2012 - Elsevier
The epidermal growth factor receptor (EGFR) pathway is one of the most dysregulated
molecular pathways in human cancers. Despite its well-established importance in tumor …
molecular pathways in human cancers. Despite its well-established importance in tumor …
The mysterious ways of ErbB2/HER2 trafficking
V Bertelsen, E Stang - Membranes, 2014 - mdpi.com
The EGFR-or ErbB-family of receptor tyrosine kinases consists of EGFR/ErbB1,
ErbB2/HER2, ErbB3/HER3 and ErbB4/HER4. Receptor activation and downstream …
ErbB2/HER2, ErbB3/HER3 and ErbB4/HER4. Receptor activation and downstream …
Regulation of sister chromatid cohesion by nuclear PD-L1
Abstract Programmed death ligand-1 (PD-L1 or B7-H1) is well known for its role in immune
checkpoint regulation, but its function inside the tumor cells has rarely been explored. Here …
checkpoint regulation, but its function inside the tumor cells has rarely been explored. Here …
EGFR signaling promotes nuclear translocation of plasma membrane protein TSPAN8 to enhance tumor progression via STAT3-mediated transcription
X Lu, L An, G Fan, L Zang, W Huang, J Li, J Liu, W Ge… - Cell Research, 2022 - nature.com
TSPAN family of proteins are generally considered to assemble as multimeric complexes on
the plasma membrane. Our previous work uncovered that TSPAN8 can translocate into the …
the plasma membrane. Our previous work uncovered that TSPAN8 can translocate into the …
Nuclear functions and subcellular trafficking mechanisms of the epidermal growth factor receptor family
Accumulating evidence suggests that various diseases, including many types of cancer,
result from alteration of subcellular protein localization and compartmentalization. Therefore …
result from alteration of subcellular protein localization and compartmentalization. Therefore …