Effects of an aged tissue niche on the immune potency of dendritic cells using simulated microgravity
Microgravity accelerates the aging of various physiological systems, and it is well
acknowledged that aged individuals and astronauts both have increased susceptibility to …
acknowledged that aged individuals and astronauts both have increased susceptibility to …
Mechanical forces amplify TCR mechanotransduction in T cell activation and function
Adoptive T cell immunotherapies, including engineered T cell receptor (eTCR) and chimeric
antigen receptor (CAR) T cell immunotherapies, have shown efficacy in treating a subset of …
antigen receptor (CAR) T cell immunotherapies, have shown efficacy in treating a subset of …
Matrix stiffening from collagen fibril density and alignment modulates YAP-mediated T-cell immune suppression
T-cells are essential components of the immune system, adapting their behavior in response
to the mechanical environments they encounter within the body. In pathological conditions …
to the mechanical environments they encounter within the body. In pathological conditions …
Application of Nanomaterials in the Repair and Regeneration of Lymphatic Organs and Corresponding Biophysical Simulation Strategies
Immune system diseases, malignant tumors, and traumatic injuries can directly damage the
structure and function of lymphoid organs, while subsequent radiotherapy, chemotherapy …
structure and function of lymphoid organs, while subsequent radiotherapy, chemotherapy …
A computational model for single cell Lamin‐A structural organization after microfluidic compression
MI Maremonti, F Causa - Biotechnology and Bioengineering, 2024 - Wiley Online Library
In recent years, nuclear mechanobiology gained a lot of attention for the study of cell
responses to external cues like adhesive forces, applied compression, and/or shear …
responses to external cues like adhesive forces, applied compression, and/or shear …
[HTML][HTML] Tug of war: Understanding the dynamic interplay of tumor biomechanical environment on dendritic cell function
Dendritic cells (DCs) play a pivotal role in bridging the innate and adaptive immune systems.
From their immature state, scavenging tissue for foreign antigens to uptake, then maturation …
From their immature state, scavenging tissue for foreign antigens to uptake, then maturation …
Matrix fibril alignment and density modulate YAP-mediated T-cell immune suppression
T-cells navigate through various mechanical environments within the body, adapting their
behavior in response to these cues. An altered extracellular matrix (ECM) characterized by …
behavior in response to these cues. An altered extracellular matrix (ECM) characterized by …
Mechano-mediated M2 macrophage polarization and immune suppression in stiffened tumor microenvironment
The tumor microenvironment (TME), which is composed of various cell types and the
extracellular matrix (ECM), plays crucial roles in cancer progression and treatment …
extracellular matrix (ECM), plays crucial roles in cancer progression and treatment …