Asthma is an inflammatory disease of the airways that may result from exposure to allergens
or other environmental irritants, resulting in bronchoconstriction, wheezing, and shortness of …

Asthma | From Bronchoconstriction to Airways Inflammation and Remodeling | American
Journal of Respiratory and Critical Care Medicine ATS Journals Logo Official Publications …

Abstract Ossovskaya, Valeria S., and Nigel W. Bunnett. Protease-Activated Receptors:
Contribution to Physiology and Disease. Physiol Rev 84: 579–621, 2004; 10.1152/physrev …

Mast cells are important components of the immune system, and they perform pro-
inflammatory as well as anti-inflammatory roles in the complex process of immune regulation …

There is compelling evidence that human mast cells contribute to the pathophysiology of
asthma. Mast cells, but not T cells or eosinophils, localize within the bronchial smooth …

Tryptases and chymases are the major proteins stored and secreted by mast cells. The
types, amounts, and properties of these serine peptidases vary by mast cell subtype, tissue …

Asthma is a complex chronic inflammatory disease of the airways that involves the activation
of many inflammatory and structural cells, all of which release inflammatory mediators that …

Although serine proteases are usually considered to act principally as degradative enzymes,
certain proteases are signaling molecules that specifically regulate cells by cleaving and …

Mast cells, which are granulocytes found in peripheral tissue, play a central role in
inflammatory and immediate allergic reactions. β‐Tryptase is a neutral serine protease and …

The presence of mast cells near capillary sprouting sites suggests an association between
mast cells and angiogenesis. However, the role of mast cells in blood vessel development …