Transforming growth factor (TGF)-β is an evolutionarily conserved pleiotropic factor that
regulates a myriad of biological processes including development, tissue regeneration …

Eosinophilic esophagitis (EoE) has emerged over the past 2 decades as a major cause of
upper gastrointestinal morbidity. Over this time, the epidemiology of EoE has also rapidly …

Asthma is a chronic disease of the airways, which affects more than 350 million people
worldwide. It is the most common chronic disease in children, affecting at least 30 million …

Eosinophilic esophagitis is an emerging disease that is distinguished from
gastroesophageal reflux disease by the expression of a unique esophageal transcriptome …

STAT6 (signal transducer and activator of transcription 6) is a transcription factor that plays a
central role in the pathophysiology of allergic inflammation. We have identified 16 patients …

Regulatory T (Treg) cells expressing the transcription factor forkhead box P3 (Foxp3) play a
requisite role in the maintenance of immunological homeostasis and prevention of …

Loeys–Dietz syndrome is a connective tissue disorder predisposing individuals to aortic and
arterial aneurysms. Presenting with a wide spectrum of multisystem involvement, medical …

Autoimmune diseases, such as Systemic Lupus Erythematosus (SLE) or Rheumatoid
Arthritis (RA) are characterized by the breakdown of immunological tolerance. Defects of …

Eosinophilic esophagitis (EoE) is a chronic inflammatory disorder associated with allergic
hypersensitivity to food. We interrogated> 1.5 million genetic variants in EoE cases of …

Evans syndrome (ES) is a rare severe autoimmune disorder characterized by the
combination of autoimmune hemolytic anemia and immune thrombocytopenia. In most …