Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases

JS Loh, WQ Mak, LKS Tan, CX Ng, HH Chan… - … and Targeted Therapy, 2024 - nature.com
The human gastrointestinal tract is populated with a diverse microbial community. The vast
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …

Signalling cognition: the gut microbiota and hypothalamic-pituitary-adrenal axis

JA Rusch, BT Layden, LR Dugas - Frontiers in endocrinology, 2023 - frontiersin.org
Cognitive function in humans depends on the complex and interplay between multiple body
systems, including the hypothalamic-pituitary-adrenal (HPA) axis. The gut microbiota, which …

Probiotics for neurodegenerative diseases: a systemic review

S Ojha, N Patil, M Jain, C Kole, P Kaushik - Microorganisms, 2023 - mdpi.com
Neurodegenerative disorders (ND) are a group of conditions that affect the neurons in the
brain and spinal cord, leading to their degeneration and eventually causing the loss of …

Dietary fibre confers therapeutic effects in a preclinical model of Huntington's disease

C Gubert, G Kong, C Costello, CD Adams… - Brain, Behavior, and …, 2024 - Elsevier
Huntington's disease (HD) is a neurodegenerative disorder involving psychiatric, cognitive
and motor deficits, as well as peripheral symptoms, including gastrointestinal dysfunction …

Microbiota from healthy mice alleviates cognitive decline via reshaping the gut-brain metabolic axis in diabetic mice

Q Zhao, J Chen, M Wu, X Yin, Q Jiang, H Gao… - Chemico-Biological …, 2023 - Elsevier
Diabetic cognitive decline has been associated with the gut microbial disorders, but its
potential gut-brain axis mechanisms remain unclear. Herein we transplanted the gut …

Paternal immune activation by poly I: C modulates sperm noncoding RNA profiles and causes transgenerational changes in offspring behavior

EA Kleeman, SN Reisinger, P Adithya… - Brain, Behavior, and …, 2024 - Elsevier
Paternal pre-conceptual environmental experiences, such as stress and diet, can affect
offspring brain and behavioral phenotypes via epigenetic modifications in sperm …

Gut microbiota and Alzheimer's disease: how to study and apply their relationship

NM Nguyen, J Cho, C Lee - International journal of molecular sciences, 2023 - mdpi.com
Gut microbiota (GM), the microorganisms in the gastrointestinal tract, contribute to the
regulation of brain homeostasis through bidirectional communication between the gut and …

The microbiota–gut–brain axis in Huntington's disease: pathogenic mechanisms and therapeutic targets

MN Ekwudo, C Gubert, AJ Hannan - The FEBS Journal, 2024 - Wiley Online Library
Huntington's disease (HD) is a currently incurable neurogenerative disorder and is typically
characterized by progressive movement disorder (including chorea), cognitive deficits …

Therapeutics for neurodegenerative diseases by targeting the gut microbiome: from bench to bedside

YY Ma, X Li, JT Yu, YJ Wang - Translational Neurodegeneration, 2024 - Springer
The aetiologies and origins of neurodegenerative diseases, such as Alzheimer's disease
(AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and Huntington's …

What the gut tells the brain—Is there a link between microbiota and Huntington's disease?

D Wronka, A Karlik, JO Misiorek, L Przybyl - International Journal of …, 2023 - mdpi.com
The human intestinal microbiota is a diverse and dynamic microenvironment that forms a
complex, bi-directional relationship with the host. The microbiome takes part in the digestion …