Mendelian randomization: concepts and scope
RC Richmond, GD Smith - Cold Spring …, 2022 - perspectivesinmedicine.cshlp.org
Mendelian randomization (MR) is a method of studying the causal effects of modifiable
exposures (ie, potential risk factors) on health, social, and economic outcomes using genetic …
exposures (ie, potential risk factors) on health, social, and economic outcomes using genetic …
Evaluating the potential role of pleiotropy in Mendelian randomization studies
Pleiotropy, the phenomenon of a single genetic variant influencing multiple traits, is likely
widespread in the human genome. If pleiotropy arises because the single nucleotide …
widespread in the human genome. If pleiotropy arises because the single nucleotide …
[HTML][HTML] Guidelines for performing Mendelian randomization investigations: update for summer 2023
This paper provides guidelines for performing Mendelian randomization investigations. It is
aimed at practitioners seeking to undertake analyses and write up their findings, and at …
aimed at practitioners seeking to undertake analyses and write up their findings, and at …
Statistical inference in two-sample summary-data Mendelian randomization using robust adjusted profile score
Statistical inference in two-sample summary-data Mendelian randomization using robust
adjusted profile score Page 1 The Annals of Statistics 2020, Vol. 48, No. 3, 1742–1769 https://doi.org/10.1214/19-AOS1866 …
adjusted profile score Page 1 The Annals of Statistics 2020, Vol. 48, No. 3, 1742–1769 https://doi.org/10.1214/19-AOS1866 …
Recent developments in Mendelian randomization studies
Abstract Purpose of Review Mendelian randomization (MR) is a strategy for evaluating
causality in observational epidemiological studies. MR exploits the fact that genotypes are …
causality in observational epidemiological studies. MR exploits the fact that genotypes are …
[图书][B] Mendelian randomization: methods for causal inference using genetic variants
S Burgess, SG Thompson - 2021 - books.google.com
Mendelian Randomization: Methods For Causal Inference Using Genetic Variants provides
thorough coverage of the methods and practical elements of Mendelian randomization …
thorough coverage of the methods and practical elements of Mendelian randomization …
Inferring causal relationships between risk factors and outcomes from genome-wide association study data
An observational correlation between a suspected risk factor and an outcome does not
necessarily imply that interventions on levels of the risk factor will have a causal impact on …
necessarily imply that interventions on levels of the risk factor will have a causal impact on …
Understanding the assumptions underlying instrumental variable analyses: a brief review of falsification strategies and related tools
J Labrecque, SA Swanson - Current epidemiology reports, 2018 - Springer
Abstract Purpose of Review Instrumental variable (IV) methods continue to be applied to
questions ranging from genetic to social epidemiology. In the epidemiologic literature …
questions ranging from genetic to social epidemiology. In the epidemiologic literature …
Understanding the assumptions underlying Mendelian randomization
With the rapidly increasing availability of large genetic data sets in recent years, Mendelian
Randomization (MR) has quickly gained popularity as a novel secondary analysis method …
Randomization (MR) has quickly gained popularity as a novel secondary analysis method …
Addressing the credibility crisis in Mendelian randomization
Background Genome-wide association studies have enabled Mendelian randomization
analyses to be performed at an industrial scale. Two-sample summary data Mendelian …
analyses to be performed at an industrial scale. Two-sample summary data Mendelian …