Hereditary defects in the repair of DNA damage are implicated in a variety of diseases, many
of which are typified by neurological dysfunction and/or increased genetic instability and …

Reactive oxygen species continuously assault the structure of DNA resulting in oxidation
and fragmentation of the nucleobases. Both oxidative DNA damage itself and its repair …

Base excision repair (BER) is an evolutionarily conserved process for maintaining genomic
integrity by eliminating several dozen damaged (oxidized or alkylated) or inappropriate …

Excess reactive oxygen species production and free radical formation can lead to oxidative
stress that can damage cells, tissues, and organs. Cellular oxidative stress is defined as the …

DNA single-strand breaks can arise indirectly, as normal intermediates of DNA base
excision repair, or directly from damage to deoxyribose. Because single-strand breaks are …

Significance: Human apurinic/apyrimidinic endonuclease 1 (APE1, also known as REF-1)
was isolated based on its ability to cleave at AP sites in DNA or activate the DNA binding …

Genetic variations in DNA repair genes are thought to modulate DNA repair capacity and
are suggested to be related to cancer risk. However, epidemiologic findings have been …

DNA continuously suffers the loss of its constituent bases, and thereby, a loss of potentially
vital genetic information. Sites of missing bases—termed abasic or apurinic/apyrimidinic …

The major human AP endonuclease APE1 (HAP1, APEX, Ref1) initiates the repair of abasic
sites generated either spontaneously, from attack of bases by free radicals, or during the …

DNA damage is a natural hazard of life. The most common DNA lesions are base, sugar,
and single-strand break damage resulting from oxidation, alkylation, deamination, and …